Health benefits of late-onset metformin treatment every other week in mice
Intermittent use of metformin improves healthspan in old mice Chronic daily exposure to a high dose of metformin (e.g., 1% w/w) shortens lifespan of non-diabetic mice, although in the short term this treatment confers a similar pattern of gene expression and phenotypes consistent with the benefits o...
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Autores principales: | Irene Alfaras, Sarah J. Mitchell, Hector Mora, Darisbeth Rosario Lugo, Alessandra Warren, Ignacio Navas-Enamorado, Vickie Hoffmann, Christopher Hine, James R. Mitchell, David G. Le Couteur, Victoria C. Cogger, Michel Bernier, Rafael de Cabo |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/152539cd501d45ffb8c1f8e7c9698a5c |
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