Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

Samsonova et al. show a cooperative association of Lin28 and YB-1 for their target mRNA through their cold-shock domain, which is a conserved β-barrel structure that binds to single-stranded RNA. This study suggests that the association of Lin28 with YB-1 in mRNPs may contribute to the translational...

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Autores principales:	Anastasiia Samsonova, Krystel El Hage, Bénédicte Desforges, Vandana Joshi, Marie-Jeanne Clément, Guillaume Lambert, Hélène Henrie, Nicolas Babault, Pierrick Craveur, Rachid C. Maroun, Emilie Steiner, Ahmed Bouhss, Alexandre Maucuer, Dmitry N. Lyabin, Lev P. Ovchinnikov, Loic Hamon, David Pastré
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/15258b4c3a3942419e49124926949c3e
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spelling	oai:doaj.org-article:15258b4c3a3942419e49124926949c3e2021-12-02T13:17:48ZLin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain10.1038/s42003-021-01862-32399-3642https://doaj.org/article/15258b4c3a3942419e49124926949c3e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01862-3https://doaj.org/toc/2399-3642Samsonova et al. show a cooperative association of Lin28 and YB-1 for their target mRNA through their cold-shock domain, which is a conserved β-barrel structure that binds to single-stranded RNA. This study suggests that the association of Lin28 with YB-1 in mRNPs may contribute to the translational plasticity during development and the adaptation of cancer cells to adverse environments.Anastasiia SamsonovaKrystel El HageBénédicte DesforgesVandana JoshiMarie-Jeanne ClémentGuillaume LambertHélène HenrieNicolas BabaultPierrick CraveurRachid C. MarounEmilie SteinerAhmed BouhssAlexandre MaucuerDmitry N. LyabinLev P. OvchinnikovLoic HamonDavid PastréNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Anastasiia Samsonova Krystel El Hage Bénédicte Desforges Vandana Joshi Marie-Jeanne Clément Guillaume Lambert Hélène Henrie Nicolas Babault Pierrick Craveur Rachid C. Maroun Emilie Steiner Ahmed Bouhss Alexandre Maucuer Dmitry N. Lyabin Lev P. Ovchinnikov Loic Hamon David Pastré Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain
description	Samsonova et al. show a cooperative association of Lin28 and YB-1 for their target mRNA through their cold-shock domain, which is a conserved β-barrel structure that binds to single-stranded RNA. This study suggests that the association of Lin28 with YB-1 in mRNPs may contribute to the translational plasticity during development and the adaptation of cancer cells to adverse environments.
format	article
author	Anastasiia Samsonova Krystel El Hage Bénédicte Desforges Vandana Joshi Marie-Jeanne Clément Guillaume Lambert Hélène Henrie Nicolas Babault Pierrick Craveur Rachid C. Maroun Emilie Steiner Ahmed Bouhss Alexandre Maucuer Dmitry N. Lyabin Lev P. Ovchinnikov Loic Hamon David Pastré
author_facet	Anastasiia Samsonova Krystel El Hage Bénédicte Desforges Vandana Joshi Marie-Jeanne Clément Guillaume Lambert Hélène Henrie Nicolas Babault Pierrick Craveur Rachid C. Maroun Emilie Steiner Ahmed Bouhss Alexandre Maucuer Dmitry N. Lyabin Lev P. Ovchinnikov Loic Hamon David Pastré
author_sort	Anastasiia Samsonova
title	Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain
title_short	Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain
title_full	Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain
title_fullStr	Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain
title_full_unstemmed	Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain
title_sort	lin28, a major translation reprogramming factor, gains access to yb-1-packaged mrna through its cold-shock domain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15258b4c3a3942419e49124926949c3e
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Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

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