Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells

Detailed characterizations of human lung tissue-resident natural killer (trNK) cells, which potentially regulate local immune responses, is still lacking. Here the authors show that lung CD69+ CD16– NK cells express tissue-residency markers, produce effector cytokines, and are distinct, feature-wise...

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Autores principales:	Nicole Marquardt, Eliisa Kekäläinen, Puran Chen, Magda Lourda, Jennifer N. Wilson, Marlena Scharenberg, Per Bergman, Mamdoh Al-Ameri, Joanna Hård, Jeffrey E. Mold, Hans-Gustaf Ljunggren, Jakob Michaëlsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/152697cfa0e24e018fa257edf3a843b8
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spelling	oai:doaj.org-article:152697cfa0e24e018fa257edf3a843b82021-12-02T15:35:59ZUnique transcriptional and protein-expression signature in human lung tissue-resident NK cells10.1038/s41467-019-11632-92041-1723https://doaj.org/article/152697cfa0e24e018fa257edf3a843b82019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11632-9https://doaj.org/toc/2041-1723Detailed characterizations of human lung tissue-resident natural killer (trNK) cells, which potentially regulate local immune responses, is still lacking. Here the authors show that lung CD69+ CD16– NK cells express tissue-residency markers, produce effector cytokines, and are distinct, feature-wise, from lung CD8+ memory T cells or trNK in other tissues.Nicole MarquardtEliisa KekäläinenPuran ChenMagda LourdaJennifer N. WilsonMarlena ScharenbergPer BergmanMamdoh Al-AmeriJoanna HårdJeffrey E. MoldHans-Gustaf LjunggrenJakob MichaëlssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicole Marquardt Eliisa Kekäläinen Puran Chen Magda Lourda Jennifer N. Wilson Marlena Scharenberg Per Bergman Mamdoh Al-Ameri Joanna Hård Jeffrey E. Mold Hans-Gustaf Ljunggren Jakob Michaëlsson Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
description	Detailed characterizations of human lung tissue-resident natural killer (trNK) cells, which potentially regulate local immune responses, is still lacking. Here the authors show that lung CD69+ CD16– NK cells express tissue-residency markers, produce effector cytokines, and are distinct, feature-wise, from lung CD8+ memory T cells or trNK in other tissues.
format	article
author	Nicole Marquardt Eliisa Kekäläinen Puran Chen Magda Lourda Jennifer N. Wilson Marlena Scharenberg Per Bergman Mamdoh Al-Ameri Joanna Hård Jeffrey E. Mold Hans-Gustaf Ljunggren Jakob Michaëlsson
author_facet	Nicole Marquardt Eliisa Kekäläinen Puran Chen Magda Lourda Jennifer N. Wilson Marlena Scharenberg Per Bergman Mamdoh Al-Ameri Joanna Hård Jeffrey E. Mold Hans-Gustaf Ljunggren Jakob Michaëlsson
author_sort	Nicole Marquardt
title	Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
title_short	Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
title_full	Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
title_fullStr	Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
title_full_unstemmed	Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
title_sort	unique transcriptional and protein-expression signature in human lung tissue-resident nk cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/152697cfa0e24e018fa257edf3a843b8
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Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells

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