Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults

Abstract Inflammatory biomarkers in exhaled breath condensate (EBC) are measured to estimate the effects of air pollution on humans. The present study was conducted to investigate the relationship between particulate matter and inflammatory biomarkers in blood plasma and exhaled air in young adults....

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Autores principales:	Morteza Seifi, Noushin Rastkari, Mohammad Sadegh Hassanvand, Kazem Naddafi, Ramin Nabizadeh, Shahrokh Nazmara, Homa Kashani, Ahad Zare, Zahra Pourpak, Seyed Yaser Hashemi, Masud Yunesian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/152901656a084b38a64f17deb6c3f16e
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spelling	oai:doaj.org-article:152901656a084b38a64f17deb6c3f16e2021-12-02T17:45:12ZInvestigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults10.1038/s41598-021-92333-62045-2322https://doaj.org/article/152901656a084b38a64f17deb6c3f16e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92333-6https://doaj.org/toc/2045-2322Abstract Inflammatory biomarkers in exhaled breath condensate (EBC) are measured to estimate the effects of air pollution on humans. The present study was conducted to investigate the relationship between particulate matter and inflammatory biomarkers in blood plasma and exhaled air in young adults. The obtained results were compared in two periods; i.e., winter and summer. GRIMM Dust Monitors were used to measure PM10, PM2.5, and PM1 in indoor and outdoor air. A total of 40 healthy young adults exhaling air condensate were collected. Then, biomarkers of interleukin-6 (IL-6), Nitrosothiols (RS-NOs), and Tumor necrosis factor-soluble receptor-II (sTNFRII) were measured by 96 wells method ELISA and commercial kits (HS600B R&D Kit and ALX-850–037-KI01) in EBC while interleukin-6 (IL-6), sTNFRII and White Blood Cell (WBC) were measured in blood plasma in two periods of February 2013 (winter) and May 2013 (summer). Significant association was found between particulate matter and the white blood cell count (p < 0.001), as well as plasma sTNFRII levels (p-value = 0.001). No significant relationship was found between particulate matter with RS-NOs (p = 0.128), EBC RSNOs (p-value = 0.128), and plasma IL-6 (p-value = 0.167). In addition, there was no significant relationship between interleukin-6 of exhaled air with interleukin-6 of plasma (p-value < 0.792 in the first period and < 0.890 in the second period). sTNFRII was not detected in EBC. Considering the direct effect between increasing some biomarkers in blood and EBC and particulate matter, it is concluded that air pollution causes this increasing.Morteza SeifiNoushin RastkariMohammad Sadegh HassanvandKazem NaddafiRamin NabizadehShahrokh NazmaraHoma KashaniAhad ZareZahra PourpakSeyed Yaser HashemiMasud YunesianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Morteza Seifi Noushin Rastkari Mohammad Sadegh Hassanvand Kazem Naddafi Ramin Nabizadeh Shahrokh Nazmara Homa Kashani Ahad Zare Zahra Pourpak Seyed Yaser Hashemi Masud Yunesian Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults
description	Abstract Inflammatory biomarkers in exhaled breath condensate (EBC) are measured to estimate the effects of air pollution on humans. The present study was conducted to investigate the relationship between particulate matter and inflammatory biomarkers in blood plasma and exhaled air in young adults. The obtained results were compared in two periods; i.e., winter and summer. GRIMM Dust Monitors were used to measure PM10, PM2.5, and PM1 in indoor and outdoor air. A total of 40 healthy young adults exhaling air condensate were collected. Then, biomarkers of interleukin-6 (IL-6), Nitrosothiols (RS-NOs), and Tumor necrosis factor-soluble receptor-II (sTNFRII) were measured by 96 wells method ELISA and commercial kits (HS600B R&D Kit and ALX-850–037-KI01) in EBC while interleukin-6 (IL-6), sTNFRII and White Blood Cell (WBC) were measured in blood plasma in two periods of February 2013 (winter) and May 2013 (summer). Significant association was found between particulate matter and the white blood cell count (p < 0.001), as well as plasma sTNFRII levels (p-value = 0.001). No significant relationship was found between particulate matter with RS-NOs (p = 0.128), EBC RSNOs (p-value = 0.128), and plasma IL-6 (p-value = 0.167). In addition, there was no significant relationship between interleukin-6 of exhaled air with interleukin-6 of plasma (p-value < 0.792 in the first period and < 0.890 in the second period). sTNFRII was not detected in EBC. Considering the direct effect between increasing some biomarkers in blood and EBC and particulate matter, it is concluded that air pollution causes this increasing.
format	article
author	Morteza Seifi Noushin Rastkari Mohammad Sadegh Hassanvand Kazem Naddafi Ramin Nabizadeh Shahrokh Nazmara Homa Kashani Ahad Zare Zahra Pourpak Seyed Yaser Hashemi Masud Yunesian
author_facet	Morteza Seifi Noushin Rastkari Mohammad Sadegh Hassanvand Kazem Naddafi Ramin Nabizadeh Shahrokh Nazmara Homa Kashani Ahad Zare Zahra Pourpak Seyed Yaser Hashemi Masud Yunesian
author_sort	Morteza Seifi
title	Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults
title_short	Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults
title_full	Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults
title_fullStr	Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults
title_full_unstemmed	Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults
title_sort	investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/152901656a084b38a64f17deb6c3f16e
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Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults

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