Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma
Circulating tumor cells (CTCs) and cell-free DNA (cfDNA) enables characterization of a patient’s cancer. Here, the authors analyse CTCs, cfDNA, and tumor biopsies from multiple myeloma patients to show these approaches are complementary for mutation detection, together enabling a greater fraction of...
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Nature Portfolio
2018
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oai:doaj.org-article:152a39cf0415407e9126a36af80c7f2a2021-12-02T15:34:18ZWhole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma10.1038/s41467-018-04001-52041-1723https://doaj.org/article/152a39cf0415407e9126a36af80c7f2a2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04001-5https://doaj.org/toc/2041-1723Circulating tumor cells (CTCs) and cell-free DNA (cfDNA) enables characterization of a patient’s cancer. Here, the authors analyse CTCs, cfDNA, and tumor biopsies from multiple myeloma patients to show these approaches are complementary for mutation detection, together enabling a greater fraction of patient tumors to be profiled.S. ManierJ. ParkM. CapellettiM. BustorosS. S. FreemanG. HaJ. RhoadesC. J. LiuD. HuynhS. C. ReedG. GydushK. Z. SalemD. RotemC. FreymondA. YosefA. Perilla-GlenL. GarderetE. M. Van AllenS. KumarJ. C. LoveG. GetzV. A. AdalsteinssonI. M. GhobrialNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q S. Manier J. Park M. Capelletti M. Bustoros S. S. Freeman G. Ha J. Rhoades C. J. Liu D. Huynh S. C. Reed G. Gydush K. Z. Salem D. Rotem C. Freymond A. Yosef A. Perilla-Glen L. Garderet E. M. Van Allen S. Kumar J. C. Love G. Getz V. A. Adalsteinsson I. M. Ghobrial Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma |
| description |
Circulating tumor cells (CTCs) and cell-free DNA (cfDNA) enables characterization of a patient’s cancer. Here, the authors analyse CTCs, cfDNA, and tumor biopsies from multiple myeloma patients to show these approaches are complementary for mutation detection, together enabling a greater fraction of patient tumors to be profiled. |
| format |
article |
| author |
S. Manier J. Park M. Capelletti M. Bustoros S. S. Freeman G. Ha J. Rhoades C. J. Liu D. Huynh S. C. Reed G. Gydush K. Z. Salem D. Rotem C. Freymond A. Yosef A. Perilla-Glen L. Garderet E. M. Van Allen S. Kumar J. C. Love G. Getz V. A. Adalsteinsson I. M. Ghobrial |
| author_facet |
S. Manier J. Park M. Capelletti M. Bustoros S. S. Freeman G. Ha J. Rhoades C. J. Liu D. Huynh S. C. Reed G. Gydush K. Z. Salem D. Rotem C. Freymond A. Yosef A. Perilla-Glen L. Garderet E. M. Van Allen S. Kumar J. C. Love G. Getz V. A. Adalsteinsson I. M. Ghobrial |
| author_sort |
S. Manier |
| title |
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma |
| title_short |
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma |
| title_full |
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma |
| title_fullStr |
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma |
| title_full_unstemmed |
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma |
| title_sort |
whole-exome sequencing of cell-free dna and circulating tumor cells in multiple myeloma |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/152a39cf0415407e9126a36af80c7f2a |
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