The associations of incretin hormone concentration with gestational diabetes mellitus

Background: Enteropancreatic hormonal system disorder is a possible reason for β-cell dysfunction and carbohydrate metabolism disorder among pregnant women. However, no information is available about the state of enteroinsulin hormones [glucagon, glucose-dependent insulinotropic peptide (GIP), gluca...

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Autores principales:	Tatiana V. Saprina, Ekaterina S. Timokhina, Olga K. Goncharevich, Svetlana V. Budeeva, Tatiana S. Prokhorenko, Lyubov A. Tashireva, Nadezhda N. Musina, Irina V. Dronova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	gestational diabetes mellitus incretins glucagon glucagon-like peptide-1 glucagon-like peptide-2 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/152a9f78f6864022a6056a32d20297ce
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spelling	oai:doaj.org-article:152a9f78f6864022a6056a32d20297ce2021-11-14T09:00:20ZThe associations of incretin hormone concentration with gestational diabetes mellitus2072-03512072-037810.14341/DM2004134-37https://doaj.org/article/152a9f78f6864022a6056a32d20297ce2016-05-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7026https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background: Enteropancreatic hormonal system disorder is a possible reason for β-cell dysfunction and carbohydrate metabolism disorder among pregnant women. However, no information is available about the state of enteroinsulin hormones [glucagon, glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide1 (GLP-1) and GLP-2] during pregnancy. The role of enteroinsulin hormones in the development of carbohydrate metabolism disorder during pregnancy is poorly understood. Aim: To quantify and compare incretin hormone secretion in groups of pregnant women with and without gestational diabetes mellitus (GDM). Materials and methods: The study included 80 patients, 50 of whom had GDM, and the control group consisted of 30 pregnant women without GDM. All patients underwent an oral glucose tolerance test; glycated haemoglobin (HbA1c) estimation; ferritin, transferrin, basal and postprandial glucagon estimation; GLP-1 and GLP-2 estimation. Results: Basal glucagon and GLP-1 levels were significantly higher (p <0. 05) in the group of women with GDM than in the control group. The most significant differences in GLP-1, basal and postprandial glucagon levels were observed during the first trimester of pregnancy. Conclusion: High GLP-1 levels in the group of women with GDM may reflect a state of ‘incretin resistance’, which is similar to hyperinsulinemia in the early stages of type 2 diabetes mellitus.Tatiana V. SaprinaEkaterina S. TimokhinaOlga K. GoncharevichSvetlana V. BudeevaTatiana S. ProkhorenkoLyubov A. TashirevaNadezhda N. MusinaIrina V. DronovaEndocrinology Research Centrearticlegestational diabetes mellitusincretinsglucagonglucagon-like peptide-1glucagon-like peptide-2Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 2, Pp 150-157 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	gestational diabetes mellitus incretins glucagon glucagon-like peptide-1 glucagon-like peptide-2 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	gestational diabetes mellitus incretins glucagon glucagon-like peptide-1 glucagon-like peptide-2 Nutritional diseases. Deficiency diseases RC620-627 Tatiana V. Saprina Ekaterina S. Timokhina Olga K. Goncharevich Svetlana V. Budeeva Tatiana S. Prokhorenko Lyubov A. Tashireva Nadezhda N. Musina Irina V. Dronova The associations of incretin hormone concentration with gestational diabetes mellitus
description	Background: Enteropancreatic hormonal system disorder is a possible reason for β-cell dysfunction and carbohydrate metabolism disorder among pregnant women. However, no information is available about the state of enteroinsulin hormones [glucagon, glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide1 (GLP-1) and GLP-2] during pregnancy. The role of enteroinsulin hormones in the development of carbohydrate metabolism disorder during pregnancy is poorly understood. Aim: To quantify and compare incretin hormone secretion in groups of pregnant women with and without gestational diabetes mellitus (GDM). Materials and methods: The study included 80 patients, 50 of whom had GDM, and the control group consisted of 30 pregnant women without GDM. All patients underwent an oral glucose tolerance test; glycated haemoglobin (HbA1c) estimation; ferritin, transferrin, basal and postprandial glucagon estimation; GLP-1 and GLP-2 estimation. Results: Basal glucagon and GLP-1 levels were significantly higher (p <0. 05) in the group of women with GDM than in the control group. The most significant differences in GLP-1, basal and postprandial glucagon levels were observed during the first trimester of pregnancy. Conclusion: High GLP-1 levels in the group of women with GDM may reflect a state of ‘incretin resistance’, which is similar to hyperinsulinemia in the early stages of type 2 diabetes mellitus.
format	article
author	Tatiana V. Saprina Ekaterina S. Timokhina Olga K. Goncharevich Svetlana V. Budeeva Tatiana S. Prokhorenko Lyubov A. Tashireva Nadezhda N. Musina Irina V. Dronova
author_facet	Tatiana V. Saprina Ekaterina S. Timokhina Olga K. Goncharevich Svetlana V. Budeeva Tatiana S. Prokhorenko Lyubov A. Tashireva Nadezhda N. Musina Irina V. Dronova
author_sort	Tatiana V. Saprina
title	The associations of incretin hormone concentration with gestational diabetes mellitus
title_short	The associations of incretin hormone concentration with gestational diabetes mellitus
title_full	The associations of incretin hormone concentration with gestational diabetes mellitus
title_fullStr	The associations of incretin hormone concentration with gestational diabetes mellitus
title_full_unstemmed	The associations of incretin hormone concentration with gestational diabetes mellitus
title_sort	associations of incretin hormone concentration with gestational diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/152a9f78f6864022a6056a32d20297ce
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The associations of incretin hormone concentration with gestational diabetes mellitus

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