Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak

Abstract The sharp high dose Bragg peak of a carbon-ion beam helps it to deliver the highest dosage to the malignant cells while leaving the normal cells relatively unharmed. However, the precise range in which it distributes dosages that significantly induce cell death or genotoxicity surrounding i...

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Autores principales:	Dylan J. Buglewicz, Austin B. Banks, Hirokazu Hirakawa, Akira Fujimori, Takamitsu A. Kato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/152be4bcf7b74f3c865105c3a2abea99
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spelling	oai:doaj.org-article:152be4bcf7b74f3c865105c3a2abea992021-12-02T15:08:19ZMonoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak10.1038/s41598-019-42600-42045-2322https://doaj.org/article/152be4bcf7b74f3c865105c3a2abea992019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-42600-4https://doaj.org/toc/2045-2322Abstract The sharp high dose Bragg peak of a carbon-ion beam helps it to deliver the highest dosage to the malignant cells while leaving the normal cells relatively unharmed. However, the precise range in which it distributes dosages that significantly induce cell death or genotoxicity surrounding its Bragg peak remains unclear. To evaluate biological effects of carbon-ion radiation through entrance to post Bragg peak in a single biological system, CHO and xrs5 cells were cultured in T-175 cell culture flasks and irradiated with 290 MeV/n monoenergetic carbon-ions with initial dosages upon entrance to the flask of 1, 2, or 3 Gy for cell survival assays or 1 Gy for cytokinesis block micronuclei assays. Under all initial dosages, the biological Bragg peak and the highest micronuclei formation was observed at the depth of 14.5 cm. Moreover, as the initial dosage increased the range displaying a significant decrease in survival fraction increased as well (P < 0.0001). Intriguingly from 1 Gy to 3 Gy, we observed a significant increase in reappearance of colony formation depth (P < 0.05), possibly indicating the nuclear fragmentation lethality potential of the carbon-ion. By means of our single system approach, we can achieve a more comprehensive understanding of biological effects surrounding of carbon-ions Bragg peak.Dylan J. BuglewiczAustin B. BanksHirokazu HirakawaAkira FujimoriTakamitsu A. KatoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dylan J. Buglewicz Austin B. Banks Hirokazu Hirakawa Akira Fujimori Takamitsu A. Kato Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak
description	Abstract The sharp high dose Bragg peak of a carbon-ion beam helps it to deliver the highest dosage to the malignant cells while leaving the normal cells relatively unharmed. However, the precise range in which it distributes dosages that significantly induce cell death or genotoxicity surrounding its Bragg peak remains unclear. To evaluate biological effects of carbon-ion radiation through entrance to post Bragg peak in a single biological system, CHO and xrs5 cells were cultured in T-175 cell culture flasks and irradiated with 290 MeV/n monoenergetic carbon-ions with initial dosages upon entrance to the flask of 1, 2, or 3 Gy for cell survival assays or 1 Gy for cytokinesis block micronuclei assays. Under all initial dosages, the biological Bragg peak and the highest micronuclei formation was observed at the depth of 14.5 cm. Moreover, as the initial dosage increased the range displaying a significant decrease in survival fraction increased as well (P < 0.0001). Intriguingly from 1 Gy to 3 Gy, we observed a significant increase in reappearance of colony formation depth (P < 0.05), possibly indicating the nuclear fragmentation lethality potential of the carbon-ion. By means of our single system approach, we can achieve a more comprehensive understanding of biological effects surrounding of carbon-ions Bragg peak.
format	article
author	Dylan J. Buglewicz Austin B. Banks Hirokazu Hirakawa Akira Fujimori Takamitsu A. Kato
author_facet	Dylan J. Buglewicz Austin B. Banks Hirokazu Hirakawa Akira Fujimori Takamitsu A. Kato
author_sort	Dylan J. Buglewicz
title	Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak
title_short	Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak
title_full	Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak
title_fullStr	Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak
title_full_unstemmed	Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak
title_sort	monoenergetic 290 mev/n carbon-ion beam biological lethal dose distribution surrounding the bragg peak
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/152be4bcf7b74f3c865105c3a2abea99
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Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak

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