Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant

Orli Binyamin,1,* Liraz Larush,2,* Kati Frid,1 Guy Keller,1 Yael Friedman-Levi,1 Haim Ovadia,1 Oded Abramsky,1 Shlomo Magdassi,2 Ruth Gabizon1 1Department of Neurology, The Agnes Ginges Center of Human Neurogenetics, Hadassah University Hospital, 2Casali Institute of Chemistry, The Hebrew Universit...

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Autores principales:	Binyamin O, Larush L, Frid K, Keller G, Friedman-Levi Y, Ovadia H, Abramsky O, Magdassi S, Gabizon R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/152c7c4907a84835ada153f0bb35e581
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spelling	oai:doaj.org-article:152c7c4907a84835ada153f0bb35e5812021-12-02T07:13:42ZTreatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant1178-2013https://doaj.org/article/152c7c4907a84835ada153f0bb35e5812015-11-01T00:00:00Zhttps://www.dovepress.com/treatment-of-a-multiple-sclerosis-animal-model-by-a-novel-nanodrop-for-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Orli Binyamin,1,* Liraz Larush,2,* Kati Frid,1 Guy Keller,1 Yael Friedman-Levi,1 Haim Ovadia,1 Oded Abramsky,1 Shlomo Magdassi,2 Ruth Gabizon1 1Department of Neurology, The Agnes Ginges Center of Human Neurogenetics, Hadassah University Hospital, 2Casali Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel *These authors contributed equally to this work Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. In this work, we administered a nanodroplet formulation of pomegranate seed oil (PSO), denominated Nano-PSO, to mice induced for experimental autoimmune encephalomyelitis (EAE), an established model of MS. PSO comprises high levels of punicic acid, a unique polyunsaturated fatty acid considered as one of the strongest natural antioxidants. We show here that while EAE-induced mice treated with natural PSO presented some reduction in disease burden, this beneficial effect increased significantly when EAE mice were treated with Nano-PSO of specific size nanodroplets at much lower concentrations of the oil. Pathological examinations revealed that Nano-PSO administration dramatically reduced demyelination and oxidation of lipids in the brains of the affected animals, which are hallmarks of this severe neurological disease. We propose that novel formulations of natural antioxidants such as Nano-PSO may be considered for the treatment of patients suffering from demyelinating diseases. On the mechanistic side, our results demonstrate that lipid oxidation may be a seminal feature in both demyelination and neurodegeneration. Keywords: nanodrops, PSO, EAE, oxidative stress, neurodegenerationBinyamin OLarush LFrid KKeller GFriedman-Levi YOvadia HAbramsky OMagdassi SGabizon RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 7165-7174 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Binyamin O Larush L Frid K Keller G Friedman-Levi Y Ovadia H Abramsky O Magdassi S Gabizon R Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
description	Orli Binyamin,1,* Liraz Larush,2,* Kati Frid,1 Guy Keller,1 Yael Friedman-Levi,1 Haim Ovadia,1 Oded Abramsky,1 Shlomo Magdassi,2 Ruth Gabizon1 1Department of Neurology, The Agnes Ginges Center of Human Neurogenetics, Hadassah University Hospital, 2Casali Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel *These authors contributed equally to this work Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. In this work, we administered a nanodroplet formulation of pomegranate seed oil (PSO), denominated Nano-PSO, to mice induced for experimental autoimmune encephalomyelitis (EAE), an established model of MS. PSO comprises high levels of punicic acid, a unique polyunsaturated fatty acid considered as one of the strongest natural antioxidants. We show here that while EAE-induced mice treated with natural PSO presented some reduction in disease burden, this beneficial effect increased significantly when EAE mice were treated with Nano-PSO of specific size nanodroplets at much lower concentrations of the oil. Pathological examinations revealed that Nano-PSO administration dramatically reduced demyelination and oxidation of lipids in the brains of the affected animals, which are hallmarks of this severe neurological disease. We propose that novel formulations of natural antioxidants such as Nano-PSO may be considered for the treatment of patients suffering from demyelinating diseases. On the mechanistic side, our results demonstrate that lipid oxidation may be a seminal feature in both demyelination and neurodegeneration. Keywords: nanodrops, PSO, EAE, oxidative stress, neurodegeneration
format	article
author	Binyamin O Larush L Frid K Keller G Friedman-Levi Y Ovadia H Abramsky O Magdassi S Gabizon R
author_facet	Binyamin O Larush L Frid K Keller G Friedman-Levi Y Ovadia H Abramsky O Magdassi S Gabizon R
author_sort	Binyamin O
title	Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
title_short	Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
title_full	Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
title_fullStr	Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
title_full_unstemmed	Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
title_sort	treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/152c7c4907a84835ada153f0bb35e581
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Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant

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