Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health

Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL;...

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Autores principales:	Archana Mishra, Haq Abdul Shaik, Rakesh Kumar Sinha, Bakht Ramin Shah
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Andrographis paniculata</i> (AP) andrographolide (AGL) anti-manic anti-microbial COVID-19 epidemic immune booster Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/152d7fc36bdd49ba8cfd995da003946c
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spelling	oai:doaj.org-article:152d7fc36bdd49ba8cfd995da003946c2021-11-25T18:29:21ZAndrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health10.3390/molecules262270361420-3049https://doaj.org/article/152d7fc36bdd49ba8cfd995da003946c2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/7036https://doaj.org/toc/1420-3049Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; C<sub>20</sub>H<sub>30</sub>O<sub>5</sub>) isolated from <i>Andrographis paniculate</i> (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster.Archana MishraHaq Abdul ShaikRakesh Kumar SinhaBakht Ramin ShahMDPI AGarticle<i>Andrographis paniculata</i> (AP)andrographolide (AGL)anti-manicanti-microbialCOVID-19 epidemicimmune boosterOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 7036, p 7036 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Andrographis paniculata</i> (AP) andrographolide (AGL) anti-manic anti-microbial COVID-19 epidemic immune booster Organic chemistry QD241-441
spellingShingle	<i>Andrographis paniculata</i> (AP) andrographolide (AGL) anti-manic anti-microbial COVID-19 epidemic immune booster Organic chemistry QD241-441 Archana Mishra Haq Abdul Shaik Rakesh Kumar Sinha Bakht Ramin Shah Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health
description	Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; C<sub>20</sub>H<sub>30</sub>O<sub>5</sub>) isolated from <i>Andrographis paniculate</i> (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster.
format	article
author	Archana Mishra Haq Abdul Shaik Rakesh Kumar Sinha Bakht Ramin Shah
author_facet	Archana Mishra Haq Abdul Shaik Rakesh Kumar Sinha Bakht Ramin Shah
author_sort	Archana Mishra
title	Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health
title_short	Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health
title_full	Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health
title_fullStr	Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health
title_full_unstemmed	Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health
title_sort	andrographolide: a herbal-chemosynthetic approach for enhancing immunity, combating viral infections, and its implication on human health
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/152d7fc36bdd49ba8cfd995da003946c
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Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health

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