The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial

Introduction: Contrast-induced acute kidney injury (CI-AKI) is a known complication of cardiac interventions. Remote ischemic preconditioning (RIPC) is a non-pharmacological method which has a nephroprotective effect. Serum cystatin C (CysC) is a suitable biomarker for the early diagnosis of AKI. Ob...

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Autores principales:	Azadeh Moradkhani, Hamid Reza Samimagham, Mohammad Tamaddondar, Hossein Farshidi, Mahmood Khayatian, Sanaz Soleimani
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2021
Materias:	contrast-induced nephropathy coronary angiography serum cystatin c acute kidney injury ischemic preconditioning preconditioning Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/15333ca865d347fcb947b046dd7684c3
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spelling	oai:doaj.org-article:15333ca865d347fcb947b046dd7684c32021-11-17T08:13:58ZThe efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial2345-420210.34172/npj.2021.09https://doaj.org/article/15333ca865d347fcb947b046dd7684c32021-01-01T00:00:00Zhttps://jnephropharmacology.com/PDF/npj-10349https://doaj.org/toc/2345-4202Introduction: Contrast-induced acute kidney injury (CI-AKI) is a known complication of cardiac interventions. Remote ischemic preconditioning (RIPC) is a non-pharmacological method which has a nephroprotective effect. Serum cystatin C (CysC) is a suitable biomarker for the early diagnosis of AKI. Objectives: This study aimed to evaluate the incidence of CI-AKI after RIPC in patients undergoing coronary angiography, through assessment of CysC. Patients and Methods: Around 140 patients with stable coronary artery disease undergoing angiography were randomly allocated to two groups of RIPC and control groups. In each group, the following biomarkers were assessed: serum creatinine (Cr) and CysC at baseline, 24-hour and 48-hour serum Cr and 24-hour CysC. The endpoint was the development of AKI based on either the KDIGO criteria or a 15% increase in serum CysC. Results: No significant difference was observed between two groups regarding the incidence of AKI according to either KIDIGO criteria or by the increase of serum CysC (P =0.116 and P =0.392, respectively). Moreover, a 46.99% increase in CysC level was observed among patients with AKI during the first 24 hours after the procedure, while at the same interval, it increased only 16.01% in patients without AKI. Conclusion: RIPC with three cycles of 5-minute ischemia and 5-minute reperfusion, did not decrease serum CysC based CI-AKI or alter renal biomarkers course in patients with low risk, who underwent coronary angiography.Azadeh MoradkhaniHamid Reza SamimaghamMohammad TamaddondarHossein FarshidiMahmood KhayatianSanaz SoleimaniSociety of Diabetic Nephropathy Prevention articlecontrast-induced nephropathycoronary angiographyserum cystatin cacute kidney injuryischemic preconditioningpreconditioningTherapeutics. PharmacologyRM1-950Diseases of the genitourinary system. UrologyRC870-923ENJournal of Nephropharmacology, Vol 10, Iss 1, Pp e09-e09 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	contrast-induced nephropathy coronary angiography serum cystatin c acute kidney injury ischemic preconditioning preconditioning Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	contrast-induced nephropathy coronary angiography serum cystatin c acute kidney injury ischemic preconditioning preconditioning Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923 Azadeh Moradkhani Hamid Reza Samimagham Mohammad Tamaddondar Hossein Farshidi Mahmood Khayatian Sanaz Soleimani The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial
description	Introduction: Contrast-induced acute kidney injury (CI-AKI) is a known complication of cardiac interventions. Remote ischemic preconditioning (RIPC) is a non-pharmacological method which has a nephroprotective effect. Serum cystatin C (CysC) is a suitable biomarker for the early diagnosis of AKI. Objectives: This study aimed to evaluate the incidence of CI-AKI after RIPC in patients undergoing coronary angiography, through assessment of CysC. Patients and Methods: Around 140 patients with stable coronary artery disease undergoing angiography were randomly allocated to two groups of RIPC and control groups. In each group, the following biomarkers were assessed: serum creatinine (Cr) and CysC at baseline, 24-hour and 48-hour serum Cr and 24-hour CysC. The endpoint was the development of AKI based on either the KDIGO criteria or a 15% increase in serum CysC. Results: No significant difference was observed between two groups regarding the incidence of AKI according to either KIDIGO criteria or by the increase of serum CysC (P =0.116 and P =0.392, respectively). Moreover, a 46.99% increase in CysC level was observed among patients with AKI during the first 24 hours after the procedure, while at the same interval, it increased only 16.01% in patients without AKI. Conclusion: RIPC with three cycles of 5-minute ischemia and 5-minute reperfusion, did not decrease serum CysC based CI-AKI or alter renal biomarkers course in patients with low risk, who underwent coronary angiography.
format	article
author	Azadeh Moradkhani Hamid Reza Samimagham Mohammad Tamaddondar Hossein Farshidi Mahmood Khayatian Sanaz Soleimani
author_facet	Azadeh Moradkhani Hamid Reza Samimagham Mohammad Tamaddondar Hossein Farshidi Mahmood Khayatian Sanaz Soleimani
author_sort	Azadeh Moradkhani
title	The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial
title_short	The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial
title_full	The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial
title_fullStr	The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial
title_full_unstemmed	The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial
title_sort	efficiency of remote ischemic preconditioning on serum cystatin c-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2021
url	https://doaj.org/article/15333ca865d347fcb947b046dd7684c3
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The efficiency of remote ischemic preconditioning on serum cystatin C-based acute kidney injury in patients undergoing coronary angiography; a randomized controlled trial

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