CLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION

Abstract. We have evaluated effects of combined anti-hypertensive therapy upon the indexes of proinflammatory cytokines and clinical aspects of chronic heart failure among the patients suffering from essential hypertension (stages II-III, high and very high risk groups). The first group (n = 45) was...

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Autores principales:	T. A. Dronova, D. V. Polyakov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hypertension cytokines combined therapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/15349f14bf264a929f709dfea89fe6e2
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spelling	oai:doaj.org-article:15349f14bf264a929f709dfea89fe6e22021-11-18T08:03:38ZCLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION1563-06252313-741X10.15789/1563-0625-2009-1-49-56https://doaj.org/article/15349f14bf264a929f709dfea89fe6e22014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/139https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have evaluated effects of combined anti-hypertensive therapy upon the indexes of proinflammatory cytokines and clinical aspects of chronic heart failure among the patients suffering from essential hypertension (stages II-III, high and very high risk groups). The first group (n = 45) was treated with Enalapril + Hydrochlorothiazide, while the second group (n = 41) received Enalapril + Indapamide. Before starting the therapy, a pro-inflammatory cytokinemia was revealed, followed by a significant decrease of IL-6 and TNFαα levels in patients of the first group (p < 0,01), after two weeks of hospital treatment. During combined therapy, showed a sufficient decrease in systolic, diastolic and mean blood pressure levels for the both groups. A more pronounced regression of the mean blood pressure level was detected under Enalapril + Hydrochlorothiazide treatment (p < 0.002), accompanied by clinical improvement of chronic heart failure according to the clinical conditions rating scale (p < 0,001). Due to the correction of the systolic blood pressure level, all the patients showed adecrease in fatal risk of cardiovascular complications: they have left a high-risk group (5 to 10% SCORE) for a low risk group (< 5 % SCORE).T. A. DronovaD. V. PolyakovSPb RAACIarticlehypertensioncytokinescombined therapyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 1, Pp 49-56 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hypertension cytokines combined therapy Immunologic diseases. Allergy RC581-607
spellingShingle	hypertension cytokines combined therapy Immunologic diseases. Allergy RC581-607 T. A. Dronova D. V. Polyakov CLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION
description	Abstract. We have evaluated effects of combined anti-hypertensive therapy upon the indexes of proinflammatory cytokines and clinical aspects of chronic heart failure among the patients suffering from essential hypertension (stages II-III, high and very high risk groups). The first group (n = 45) was treated with Enalapril + Hydrochlorothiazide, while the second group (n = 41) received Enalapril + Indapamide. Before starting the therapy, a pro-inflammatory cytokinemia was revealed, followed by a significant decrease of IL-6 and TNFαα levels in patients of the first group (p < 0,01), after two weeks of hospital treatment. During combined therapy, showed a sufficient decrease in systolic, diastolic and mean blood pressure levels for the both groups. A more pronounced regression of the mean blood pressure level was detected under Enalapril + Hydrochlorothiazide treatment (p < 0.002), accompanied by clinical improvement of chronic heart failure according to the clinical conditions rating scale (p < 0,001). Due to the correction of the systolic blood pressure level, all the patients showed adecrease in fatal risk of cardiovascular complications: they have left a high-risk group (5 to 10% SCORE) for a low risk group (< 5 % SCORE).
format	article
author	T. A. Dronova D. V. Polyakov
author_facet	T. A. Dronova D. V. Polyakov
author_sort	T. A. Dronova
title	CLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION
title_short	CLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION
title_full	CLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION
title_fullStr	CLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION
title_full_unstemmed	CLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION
title_sort	clinical efficiency and influence of combined antihypertensive therapy upon cytokine profile in the patients with arterial hypertension
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/15349f14bf264a929f709dfea89fe6e2
work_keys_str_mv	AT tadronova clinicalefficiencyandinfluenceofcombinedantihypertensivetherapyuponcytokineprofileinthepatientswitharterialhypertension AT dvpolyakov clinicalefficiencyandinfluenceofcombinedantihypertensivetherapyuponcytokineprofileinthepatientswitharterialhypertension
_version_	1718422527049465856

CLINICAL EFFICIENCY AND INFLUENCE OF COMBINED ANTIHYPERTENSIVE THERAPY UPON CYTOKINE PROFILE IN THE PATIENTS WITH ARTERIAL HYPERTENSION

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