Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Introduction Psoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance. This study assessed blood parameters of lipid metabolism and markers of oxidative stress...

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Autores principales:	Aldona Pietrzak, Paweł Chabros, Ewelina Grywalska, Paweł Kiciński, Kinga Franciszkiewicz-Pietrzak, Dorota Krasowska, Grzegorz Kandzierski
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	oxidative stress cholesterol apolipoprotein lipid metabolism Medicine R
Acceso en línea:	https://doaj.org/article/15357b7e8bbc4ee2986d4b6201e2e3d3
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spelling	oai:doaj.org-article:15357b7e8bbc4ee2986d4b6201e2e3d32021-12-02T18:33:05ZSerum lipid metabolism in psoriasis and psoriatic arthritis – an update1734-19221896-915110.5114/aoms.2018.74021https://doaj.org/article/15357b7e8bbc4ee2986d4b6201e2e3d32019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Serum-lipid-metabolism-in-psoriasis-and-psoriatic-arthritis-an-update,83662,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Psoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance. This study assessed blood parameters of lipid metabolism and markers of oxidative stress in patients with psoriasis and PSA. Material and methods The study included 93 patients with psoriasis (31 patients with PSA and psoriasis, 62 patients with psoriasis vulgaris), and 60 healthy, age-matched controls. Serum concentrations of the glucose and the following lipid metabolism parameters were measured: triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), high-density lipoproteins (HDL), and apolipoproteins A and B (ApoA, ApoB). Oxidative status was determined as serum concentrations of ox-LDL/MDA Adduct. The Psoriasis Area and Severity Index (PASI) was used to determine disease severity. Results Among the three studied groups, controls had the highest HDL concentration (p < 0.001), patients with PSA had the highest ApoB concentration (p < 0.05), ApoA : ApoB ratio (p < 0.05), ox-LDL/MDA adduct concentration (p < 0.001), and TC: HDL and LDL : HDL ratios (accordingly p < 0.05, p < 0.01). In patients with psoriasis or PSA, oxidative status correlated positively with TC and ApoB concentrations. Conclusions In line with previous research, among patients with psoriasis and PSA, we found lipid metabolism abnormalities and an oxidative imbalance, which might be due to chronic inflammation in these conditions. Effective treatment of patients with psoriasis or PSA could reduce the risk of cardiovascular diseases.Aldona PietrzakPaweł ChabrosEwelina GrywalskaPaweł KicińskiKinga Franciszkiewicz-PietrzakDorota KrasowskaGrzegorz KandzierskiTermedia Publishing Housearticleoxidative stresscholesterolapolipoproteinlipid metabolismoxidative stressMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 369-375 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress cholesterol apolipoprotein lipid metabolism oxidative stress Medicine R
spellingShingle	oxidative stress cholesterol apolipoprotein lipid metabolism oxidative stress Medicine R Aldona Pietrzak Paweł Chabros Ewelina Grywalska Paweł Kiciński Kinga Franciszkiewicz-Pietrzak Dorota Krasowska Grzegorz Kandzierski Serum lipid metabolism in psoriasis and psoriatic arthritis – an update
description	Introduction Psoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance. This study assessed blood parameters of lipid metabolism and markers of oxidative stress in patients with psoriasis and PSA. Material and methods The study included 93 patients with psoriasis (31 patients with PSA and psoriasis, 62 patients with psoriasis vulgaris), and 60 healthy, age-matched controls. Serum concentrations of the glucose and the following lipid metabolism parameters were measured: triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), high-density lipoproteins (HDL), and apolipoproteins A and B (ApoA, ApoB). Oxidative status was determined as serum concentrations of ox-LDL/MDA Adduct. The Psoriasis Area and Severity Index (PASI) was used to determine disease severity. Results Among the three studied groups, controls had the highest HDL concentration (p < 0.001), patients with PSA had the highest ApoB concentration (p < 0.05), ApoA : ApoB ratio (p < 0.05), ox-LDL/MDA adduct concentration (p < 0.001), and TC: HDL and LDL : HDL ratios (accordingly p < 0.05, p < 0.01). In patients with psoriasis or PSA, oxidative status correlated positively with TC and ApoB concentrations. Conclusions In line with previous research, among patients with psoriasis and PSA, we found lipid metabolism abnormalities and an oxidative imbalance, which might be due to chronic inflammation in these conditions. Effective treatment of patients with psoriasis or PSA could reduce the risk of cardiovascular diseases.
format	article
author	Aldona Pietrzak Paweł Chabros Ewelina Grywalska Paweł Kiciński Kinga Franciszkiewicz-Pietrzak Dorota Krasowska Grzegorz Kandzierski
author_facet	Aldona Pietrzak Paweł Chabros Ewelina Grywalska Paweł Kiciński Kinga Franciszkiewicz-Pietrzak Dorota Krasowska Grzegorz Kandzierski
author_sort	Aldona Pietrzak
title	Serum lipid metabolism in psoriasis and psoriatic arthritis – an update
title_short	Serum lipid metabolism in psoriasis and psoriatic arthritis – an update
title_full	Serum lipid metabolism in psoriasis and psoriatic arthritis – an update
title_fullStr	Serum lipid metabolism in psoriasis and psoriatic arthritis – an update
title_full_unstemmed	Serum lipid metabolism in psoriasis and psoriatic arthritis – an update
title_sort	serum lipid metabolism in psoriasis and psoriatic arthritis – an update
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/15357b7e8bbc4ee2986d4b6201e2e3d3
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Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

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