Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs n...

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Detalles Bibliográficos
Autores principales: Toni Celià-Terrassa, Caleb Bastian, Daniel D. Liu, Brian Ell, Nicole M. Aiello, Yong Wei, Jose Zamalloa, Andres M. Blanco, Xiang Hang, Dmitriy Kunisky, Wenyang Li, Elizabeth D. Williams, Herschel Rabitz, Yibin Kang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/15369d2c47794345b6112dc4b6b051de
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Sumario:The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs negative feedback loop and enhances metastasis.

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