Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs n...

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Autores principales:	Toni Celià-Terrassa, Caleb Bastian, Daniel D. Liu, Brian Ell, Nicole M. Aiello, Yong Wei, Jose Zamalloa, Andres M. Blanco, Xiang Hang, Dmitriy Kunisky, Wenyang Li, Elizabeth D. Williams, Herschel Rabitz, Yibin Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15369d2c47794345b6112dc4b6b051de
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spelling	oai:doaj.org-article:15369d2c47794345b6112dc4b6b051de2021-12-02T15:33:34ZHysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability10.1038/s41467-018-07538-72041-1723https://doaj.org/article/15369d2c47794345b6112dc4b6b051de2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07538-7https://doaj.org/toc/2041-1723The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs negative feedback loop and enhances metastasis.Toni Celià-TerrassaCaleb BastianDaniel D. LiuBrian EllNicole M. AielloYong WeiJose ZamalloaAndres M. BlancoXiang HangDmitriy KuniskyWenyang LiElizabeth D. WilliamsHerschel RabitzYibin KangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Toni Celià-Terrassa Caleb Bastian Daniel D. Liu Brian Ell Nicole M. Aiello Yong Wei Jose Zamalloa Andres M. Blanco Xiang Hang Dmitriy Kunisky Wenyang Li Elizabeth D. Williams Herschel Rabitz Yibin Kang Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
description	The epithelial-mesenchymal transition (EMT) is a dynamic process that plays important roles in cancer progression and metastasis. Here, the authors characterize a non-linear hysteretic response of E-cadherin repression during TGFβ-induced EMT that is controlled by the strength of the miR-200s/ZEBs negative feedback loop and enhances metastasis.
format	article
author	Toni Celià-Terrassa Caleb Bastian Daniel D. Liu Brian Ell Nicole M. Aiello Yong Wei Jose Zamalloa Andres M. Blanco Xiang Hang Dmitriy Kunisky Wenyang Li Elizabeth D. Williams Herschel Rabitz Yibin Kang
author_facet	Toni Celià-Terrassa Caleb Bastian Daniel D. Liu Brian Ell Nicole M. Aiello Yong Wei Jose Zamalloa Andres M. Blanco Xiang Hang Dmitriy Kunisky Wenyang Li Elizabeth D. Williams Herschel Rabitz Yibin Kang
author_sort	Toni Celià-Terrassa
title	Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
title_short	Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
title_full	Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
title_fullStr	Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
title_full_unstemmed	Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
title_sort	hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/15369d2c47794345b6112dc4b6b051de
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Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability

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