Synapse loss and progress of Alzheimer’s disease -A network model

Abstract We present observational evidence from studies on primary cortical cultures from AD transgenic mice, APPSwe/PS1ΔE9 (APP/PS1) mice, for significant decrease in total spine density at DIV-15 and onward. This indicates reduction in potential healthy synapses and strength of connections among n...

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Autores principales: G. Kashyap, D. Bapat, D. Das, R. Gowaikar, R. E. Amritkar, G. Rangarajan, V. Ravindranath, G. Ambika
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/1536a4a95e344c3ba52a07cabdc745fe
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