Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide

Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide

Sher Bahadar Khan,1,2 Khalid A Alamry,2 Nedaa A Alyahyawi,3 Abdullah M Asiri1,2 1Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah, Saudi Arabia; 2Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; 3Chemistry Depa...

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Autores principales: Khan SB, Alamry KA, Alyahyawi NA, Asiri AM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
Drug delivery system
Nanohybrid
Layered double hydroxide
Cefadroxil
Drug release
Kinetics
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/1536da9cbca64827936576b80c6e5b2a
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spelling oai:doaj.org-article:1536da9cbca64827936576b80c6e5b2a2021-12-02T08:57:19ZControlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide1178-2013https://doaj.org/article/1536da9cbca64827936576b80c6e5b2a2018-05-01T00:00:00Zhttps://www.dovepress.com/controlled-release-of-organic-inorganic-nanohybridcefadroxil-intercala-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sher Bahadar Khan,1,2 Khalid A Alamry,2 Nedaa A Alyahyawi,3 Abdullah M Asiri1,2 1Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah, Saudi Arabia; 2Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; 3Chemistry Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia Background: The intercalation of an antibiotic drug, cefadroxil (CD), into the inter-gallery of Zn, Al nitrate-layered double hydroxide (LDH) was accomplished using a co-precipitation method. This formed a nanostructured organic–inorganic hybrid material that can be exploited for the preparation of a controlled release formulation. Materials and methods: The drug–LDH nanohybrid was characterized by using field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) thermogravimetric (TG) analysis, X-ray powder diffraction (XRD) and UV–visible (UV–vis) absorption spectroscopy, which confirmed the intercalation process. Release tests of nanohybrid in the presence or absence of NaCl or polyacrylamide (PAM) were performed in vitro in gastric (pH 1.2), lysosomal (pH 4.0), intestinal (pH 6.8) and blood (pH 7.4) simulated fluid using UV–vis spectroscopy. Results: At pH 1.2, LDH was dissolved and intercalated antibiotic released from ZnAl-CD in a molecular form, which led to a significant increase in the antibiotic’s solubility. Results showed that the release of drug from nanohybrid at pH 4.0, 6.8 and 7.4 was a sustained process. Conclusion: This material might reduce side effects by the release of the drug in a controlled manner. However, it was found that the presence of Cl or PAM species in the release media has a negative impact on the release behavior. The weathering mechanism is responsible for the release of CD from the nanocomposite at pH 1.2, while the mechanism of anion exchange may be responsible for the release behavior at pH 4.0, 6.8 and 7.4. A number of kinetic models were chosen to gain more insights into the mechanisms of drug release. At pH 1.2, the zero-order model most satisfactorily explained the release kinetics of CD, while the release data of CD at pH 4.0, 6.8 and 7.4 were governed by Bhaskar kinetics. Keywords: drug delivery system, ZnAl-CD LDH nanohybrid, hydrotalcite, antibiotic, drug release, kineticsKhan SBAlamry KAAlyahyawi NAAsiri AMDove Medical PressarticleDrug delivery systemNanohybridLayered double hydroxideCefadroxilDrug releaseKineticsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3203-3222 (2018)
institution DOAJ
collection DOAJ
language EN
topic Drug delivery system
Nanohybrid
Layered double hydroxide
Cefadroxil
Drug release
Kinetics
Medicine (General)
R5-920
spellingShingle Drug delivery system
Nanohybrid
Layered double hydroxide
Cefadroxil
Drug release
Kinetics
Medicine (General)
R5-920
Khan SB
Alamry KA
Alyahyawi NA
Asiri AM
Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide
description Sher Bahadar Khan,1,2 Khalid A Alamry,2 Nedaa A Alyahyawi,3 Abdullah M Asiri1,2 1Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah, Saudi Arabia; 2Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; 3Chemistry Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia Background: The intercalation of an antibiotic drug, cefadroxil (CD), into the inter-gallery of Zn, Al nitrate-layered double hydroxide (LDH) was accomplished using a co-precipitation method. This formed a nanostructured organic–inorganic hybrid material that can be exploited for the preparation of a controlled release formulation. Materials and methods: The drug–LDH nanohybrid was characterized by using field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) thermogravimetric (TG) analysis, X-ray powder diffraction (XRD) and UV–visible (UV–vis) absorption spectroscopy, which confirmed the intercalation process. Release tests of nanohybrid in the presence or absence of NaCl or polyacrylamide (PAM) were performed in vitro in gastric (pH 1.2), lysosomal (pH 4.0), intestinal (pH 6.8) and blood (pH 7.4) simulated fluid using UV–vis spectroscopy. Results: At pH 1.2, LDH was dissolved and intercalated antibiotic released from ZnAl-CD in a molecular form, which led to a significant increase in the antibiotic’s solubility. Results showed that the release of drug from nanohybrid at pH 4.0, 6.8 and 7.4 was a sustained process. Conclusion: This material might reduce side effects by the release of the drug in a controlled manner. However, it was found that the presence of Cl or PAM species in the release media has a negative impact on the release behavior. The weathering mechanism is responsible for the release of CD from the nanocomposite at pH 1.2, while the mechanism of anion exchange may be responsible for the release behavior at pH 4.0, 6.8 and 7.4. A number of kinetic models were chosen to gain more insights into the mechanisms of drug release. At pH 1.2, the zero-order model most satisfactorily explained the release kinetics of CD, while the release data of CD at pH 4.0, 6.8 and 7.4 were governed by Bhaskar kinetics. Keywords: drug delivery system, ZnAl-CD LDH nanohybrid, hydrotalcite, antibiotic, drug release, kinetics
format article
author Khan SB
Alamry KA
Alyahyawi NA
Asiri AM
author_facet Khan SB
Alamry KA
Alyahyawi NA
Asiri AM
author_sort Khan SB
title Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide
title_short Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide
title_full Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide
title_fullStr Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide
title_full_unstemmed Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide
title_sort controlled release of organic–inorganic nanohybrid:cefadroxil intercalated zn–al-layered double hydroxide
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/1536da9cbca64827936576b80c6e5b2a
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AT alyahyawina controlledreleaseoforganicndashinorganicnanohybridcefadroxilintercalatedznndashallayereddoublehydroxide
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