Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster

Luca Gabutti, Rosaria Del Giorno Department of Internal Medicine and Nephrology, Bellinzona Regional Hospital, Bellinzona, SwitzerlandArterial stiffness is a marker of vascular aging and is considered to be the most reliable parameter expressing, like an integral in mathematics, the cumulative cons...

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Autores principales:	Gabutti L, Del Giorno R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	vascular aging pulse wave velocity chronological and biological time epidemiological study Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/153b547233ba4b1489e2ed70fbe686cf
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spelling	oai:doaj.org-article:153b547233ba4b1489e2ed70fbe686cf2021-12-02T03:11:47ZVascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster1178-1998https://doaj.org/article/153b547233ba4b1489e2ed70fbe686cf2018-02-01T00:00:00Zhttps://www.dovepress.com/vascular-aging-processes-accelerate-following-a-cubic-kinetic-pulse-wa-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Luca Gabutti, Rosaria Del Giorno Department of Internal Medicine and Nephrology, Bellinzona Regional Hospital, Bellinzona, SwitzerlandArterial stiffness is a marker of vascular aging and is considered to be the most reliable parameter expressing, like an integral in mathematics, the cumulative consequences, on the vascular wall, of degenerative and adaptive changes occurring throughout life.1 The efficiency of the reparative processes, the cardiovascular risk factors (CVRF), and early life and genetic determinants, all play a relevant role.1 Among CVRF, the acceleration in arterial stiffness progression related to age is mainly influenced by hypertension.1 A pathological acceleration translates into the concept of early vascular aging, a concept that can be quantified calculating the gap between the subject’s chronological (estimated on the basis of the epidemiological data obtained in the normal population) and effective vascular age.2 Data of subpopulations without active risk factors for accelerated vascular aging can be found mainly in three large epidemiological studies, performed respectively in Portugal,3 Argentina,4 and seven different European countries (Belgium, Czech Republic, France, Greece, Italy, the Netherlands, and UK) gathered in a collaborative investigation.5 Those doing this secondary analysis were aware of the limitation related to the use of cross-sectional data to extrapolate longitudinal changes, and their aims were combining the abovementioned epidemiological data concerning the normal population to calculate with the highest possible accuracy 1) the age-related increase in acceleration of the pulse wave velocity (PWV) and to estimate both 2) the age-specific relative amount of time equivalent to that necessary to progress 1 year in vascular age at 20, and 3) the cumulative relative age calculated in year equivalents. Gabutti LDel Giorno RDove Medical Pressarticlevascular agingpulse wave velocitychronological and biological timeepidemiological studyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 305-307 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular aging pulse wave velocity chronological and biological time epidemiological study Geriatrics RC952-954.6
spellingShingle	vascular aging pulse wave velocity chronological and biological time epidemiological study Geriatrics RC952-954.6 Gabutti L Del Giorno R Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster
description	Luca Gabutti, Rosaria Del Giorno Department of Internal Medicine and Nephrology, Bellinzona Regional Hospital, Bellinzona, SwitzerlandArterial stiffness is a marker of vascular aging and is considered to be the most reliable parameter expressing, like an integral in mathematics, the cumulative consequences, on the vascular wall, of degenerative and adaptive changes occurring throughout life.1 The efficiency of the reparative processes, the cardiovascular risk factors (CVRF), and early life and genetic determinants, all play a relevant role.1 Among CVRF, the acceleration in arterial stiffness progression related to age is mainly influenced by hypertension.1 A pathological acceleration translates into the concept of early vascular aging, a concept that can be quantified calculating the gap between the subject’s chronological (estimated on the basis of the epidemiological data obtained in the normal population) and effective vascular age.2 Data of subpopulations without active risk factors for accelerated vascular aging can be found mainly in three large epidemiological studies, performed respectively in Portugal,3 Argentina,4 and seven different European countries (Belgium, Czech Republic, France, Greece, Italy, the Netherlands, and UK) gathered in a collaborative investigation.5 Those doing this secondary analysis were aware of the limitation related to the use of cross-sectional data to extrapolate longitudinal changes, and their aims were combining the abovementioned epidemiological data concerning the normal population to calculate with the highest possible accuracy 1) the age-related increase in acceleration of the pulse wave velocity (PWV) and to estimate both 2) the age-specific relative amount of time equivalent to that necessary to progress 1 year in vascular age at 20, and 3) the cumulative relative age calculated in year equivalents.
format	article
author	Gabutti L Del Giorno R
author_facet	Gabutti L Del Giorno R
author_sort	Gabutti L
title	Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster
title_short	Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster
title_full	Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster
title_fullStr	Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster
title_full_unstemmed	Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster
title_sort	vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/153b547233ba4b1489e2ed70fbe686cf
work_keys_str_mv	AT gabuttil vascularagingprocessesacceleratefollowingacubickineticpulsewavevelocityasanobjectivecounterpartthattimeasweagegoesbyfaster AT delgiornor vascularagingprocessesacceleratefollowingacubickineticpulsewavevelocityasanobjectivecounterpartthattimeasweagegoesbyfaster
_version_	1718401837735870464

Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster

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