Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

The genetic determinants of sex-specific differences in obesity are still incompletely understood. Here, the authors demonstrate that adipocyte specific loss of Trim28 in committed adipocytes leads to sex specific differences in the development of obesity, and that this phenotype is associated with...

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Autores principales:	Simon T. Bond, Emily J. King, Darren C. Henstridge, Adrian Tran, Sarah C. Moody, Christine Yang, Yingying Liu, Natalie A. Mellett, Artika P. Nath, Michael Inouye, Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Peter J. Meikle, Anna C. Calkin, Brian G. Drew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/153ba01f3e9e4f4784fc02d6c030c7c9
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spelling	oai:doaj.org-article:153ba01f3e9e4f4784fc02d6c030c7c92021-12-02T15:16:22ZDeletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance10.1038/s41467-020-20434-32041-1723https://doaj.org/article/153ba01f3e9e4f4784fc02d6c030c7c92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20434-3https://doaj.org/toc/2041-1723The genetic determinants of sex-specific differences in obesity are still incompletely understood. Here, the authors demonstrate that adipocyte specific loss of Trim28 in committed adipocytes leads to sex specific differences in the development of obesity, and that this phenotype is associated with altered metabolic flexibility and lipid metabolism.Simon T. BondEmily J. KingDarren C. HenstridgeAdrian TranSarah C. MoodyChristine YangYingying LiuNatalie A. MellettArtika P. NathMichael InouyeElizabeth J. TarlingThomas Q. de Aguiar VallimPeter J. MeikleAnna C. CalkinBrian G. DrewNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon T. Bond Emily J. King Darren C. Henstridge Adrian Tran Sarah C. Moody Christine Yang Yingying Liu Natalie A. Mellett Artika P. Nath Michael Inouye Elizabeth J. Tarling Thomas Q. de Aguiar Vallim Peter J. Meikle Anna C. Calkin Brian G. Drew Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
description	The genetic determinants of sex-specific differences in obesity are still incompletely understood. Here, the authors demonstrate that adipocyte specific loss of Trim28 in committed adipocytes leads to sex specific differences in the development of obesity, and that this phenotype is associated with altered metabolic flexibility and lipid metabolism.
format	article
author	Simon T. Bond Emily J. King Darren C. Henstridge Adrian Tran Sarah C. Moody Christine Yang Yingying Liu Natalie A. Mellett Artika P. Nath Michael Inouye Elizabeth J. Tarling Thomas Q. de Aguiar Vallim Peter J. Meikle Anna C. Calkin Brian G. Drew
author_facet	Simon T. Bond Emily J. King Darren C. Henstridge Adrian Tran Sarah C. Moody Christine Yang Yingying Liu Natalie A. Mellett Artika P. Nath Michael Inouye Elizabeth J. Tarling Thomas Q. de Aguiar Vallim Peter J. Meikle Anna C. Calkin Brian G. Drew
author_sort	Simon T. Bond
title	Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
title_short	Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
title_full	Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
title_fullStr	Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
title_full_unstemmed	Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
title_sort	deletion of trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/153ba01f3e9e4f4784fc02d6c030c7c9
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Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

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