Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures

Introduction It has been shown that long bone fractures are correlated with the inflammatory response. In the initial injury, surgical reduction and fixation of fractures induce the immunoinflammatory response. This study aimed to evaluate serum variation of inflammatory markers in patients undergoi...

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Autores principales: Mehdi Moghtadaei, Babak Otoukesh, Hamidreza Pazoki-Toroudi, Bahram Boddouhi, Ali Yeganeh
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Publicado: Termedia Publishing House 2018
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spelling oai:doaj.org-article:153d3e2c67a54119bcd7aa43486d07932021-12-02T19:15:49ZEvaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures1734-19221896-915110.5114/aoms.2016.63013https://doaj.org/article/153d3e2c67a54119bcd7aa43486d07932018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Evaluation-of-inflammatory-response-in-patients-undergoing-surgical-treatment-for,64777,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction It has been shown that long bone fractures are correlated with the inflammatory response. In the initial injury, surgical reduction and fixation of fractures induce the immunoinflammatory response. This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. Material and methods This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. The patients were randomly divided into two groups using the method of block randomization including early surgery (within 24 h) and delayed surgery (after 48 h). Serum levels of inflammatory markers in both groups including interleukin (IL)-1, 5, 6, tumor necrosis factor α (TNF-α) and interferon γ (IFN-γ) were determined using specific kits. From each patient 10 ml blood was collected for cytokine assay in their serum. Results Our findings suggest that serum levels of IL-8 were markedly decreased from 12 h until 48 h postoperatively (p < 0.05). Moreover, the results indicated that serum levels of TNF-α were significantly increased in the early hours, but after 48 h a decreasing trend was detected (p < 0.05). Furthermore, serum levels of IL-10, IFN-γ, and IL-6 were significantly increased from 12 h until 48 h postoperatively (p < 0.05). Conclusions The inflammatory status of the patient may be a useful adjunct in clinical decisions. With an improved understanding of the molecular basis of the inflammatory response, and by identifying relevant clinical markers of inflammation, surgeons can better manage the timing of surgical stabilization.Mehdi MoghtadaeiBabak OtoukeshHamidreza Pazoki-ToroudiBahram BoddouhiAli YeganehTermedia Publishing Housearticleinflammationtnfpatientfemoraliltumor necrosis factorinterleukinMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 141-145 (2018)
institution DOAJ
collection DOAJ
language EN
topic inflammation
tnf
patient
femoral
il
tumor necrosis factor
interleukin
Medicine
R
spellingShingle inflammation
tnf
patient
femoral
il
tumor necrosis factor
interleukin
Medicine
R
Mehdi Moghtadaei
Babak Otoukesh
Hamidreza Pazoki-Toroudi
Bahram Boddouhi
Ali Yeganeh
Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures
description Introduction It has been shown that long bone fractures are correlated with the inflammatory response. In the initial injury, surgical reduction and fixation of fractures induce the immunoinflammatory response. This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. Material and methods This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. The patients were randomly divided into two groups using the method of block randomization including early surgery (within 24 h) and delayed surgery (after 48 h). Serum levels of inflammatory markers in both groups including interleukin (IL)-1, 5, 6, tumor necrosis factor α (TNF-α) and interferon γ (IFN-γ) were determined using specific kits. From each patient 10 ml blood was collected for cytokine assay in their serum. Results Our findings suggest that serum levels of IL-8 were markedly decreased from 12 h until 48 h postoperatively (p < 0.05). Moreover, the results indicated that serum levels of TNF-α were significantly increased in the early hours, but after 48 h a decreasing trend was detected (p < 0.05). Furthermore, serum levels of IL-10, IFN-γ, and IL-6 were significantly increased from 12 h until 48 h postoperatively (p < 0.05). Conclusions The inflammatory status of the patient may be a useful adjunct in clinical decisions. With an improved understanding of the molecular basis of the inflammatory response, and by identifying relevant clinical markers of inflammation, surgeons can better manage the timing of surgical stabilization.
format article
author Mehdi Moghtadaei
Babak Otoukesh
Hamidreza Pazoki-Toroudi
Bahram Boddouhi
Ali Yeganeh
author_facet Mehdi Moghtadaei
Babak Otoukesh
Hamidreza Pazoki-Toroudi
Bahram Boddouhi
Ali Yeganeh
author_sort Mehdi Moghtadaei
title Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures
title_short Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures
title_full Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures
title_fullStr Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures
title_full_unstemmed Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures
title_sort evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures
publisher Termedia Publishing House
publishDate 2018
url https://doaj.org/article/153d3e2c67a54119bcd7aa43486d0793
work_keys_str_mv AT mehdimoghtadaei evaluationofinflammatoryresponseinpatientsundergoingsurgicaltreatmentforearlyanddelayedfemoralfractures
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AT hamidrezapazokitoroudi evaluationofinflammatoryresponseinpatientsundergoingsurgicaltreatmentforearlyanddelayedfemoralfractures
AT bahramboddouhi evaluationofinflammatoryresponseinpatientsundergoingsurgicaltreatmentforearlyanddelayedfemoralfractures
AT aliyeganeh evaluationofinflammatoryresponseinpatientsundergoingsurgicaltreatmentforearlyanddelayedfemoralfractures
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