Actomyosin-driven force patterning controls endocytosis at the immune synapse

The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin protrusive force at the site of antigen extraction.

Guardado en:

Detalles Bibliográficos
Autores principales:	Anita Kumari, Judith Pineau, Pablo J. Sáez, Mathieu Maurin, Danielle Lankar, Mabel San Roman, Katharina Hennig, Vanessa F. Boura, Raphael Voituriez, Mikael C. I. Karlsson, Martial Balland, Ana-Maria Lennon Dumenil, Paolo Pierobon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/153dc305ef9a4480872d0c78f10b8923
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:153dc305ef9a4480872d0c78f10b8923
record_format	dspace
spelling	oai:doaj.org-article:153dc305ef9a4480872d0c78f10b89232021-12-02T16:58:18ZActomyosin-driven force patterning controls endocytosis at the immune synapse10.1038/s41467-019-10751-72041-1723https://doaj.org/article/153dc305ef9a4480872d0c78f10b89232019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10751-7https://doaj.org/toc/2041-1723The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin protrusive force at the site of antigen extraction.Anita KumariJudith PineauPablo J. SáezMathieu MaurinDanielle LankarMabel San RomanKatharina HennigVanessa F. BouraRaphael VoituriezMikael C. I. KarlssonMartial BallandAna-Maria Lennon DumenilPaolo PierobonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anita Kumari Judith Pineau Pablo J. Sáez Mathieu Maurin Danielle Lankar Mabel San Roman Katharina Hennig Vanessa F. Boura Raphael Voituriez Mikael C. I. Karlsson Martial Balland Ana-Maria Lennon Dumenil Paolo Pierobon Actomyosin-driven force patterning controls endocytosis at the immune synapse
description	The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin protrusive force at the site of antigen extraction.
format	article
author	Anita Kumari Judith Pineau Pablo J. Sáez Mathieu Maurin Danielle Lankar Mabel San Roman Katharina Hennig Vanessa F. Boura Raphael Voituriez Mikael C. I. Karlsson Martial Balland Ana-Maria Lennon Dumenil Paolo Pierobon
author_facet	Anita Kumari Judith Pineau Pablo J. Sáez Mathieu Maurin Danielle Lankar Mabel San Roman Katharina Hennig Vanessa F. Boura Raphael Voituriez Mikael C. I. Karlsson Martial Balland Ana-Maria Lennon Dumenil Paolo Pierobon
author_sort	Anita Kumari
title	Actomyosin-driven force patterning controls endocytosis at the immune synapse
title_short	Actomyosin-driven force patterning controls endocytosis at the immune synapse
title_full	Actomyosin-driven force patterning controls endocytosis at the immune synapse
title_fullStr	Actomyosin-driven force patterning controls endocytosis at the immune synapse
title_full_unstemmed	Actomyosin-driven force patterning controls endocytosis at the immune synapse
title_sort	actomyosin-driven force patterning controls endocytosis at the immune synapse
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/153dc305ef9a4480872d0c78f10b8923
work_keys_str_mv	AT anitakumari actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT judithpineau actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT pablojsaez actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT mathieumaurin actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT daniellelankar actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT mabelsanroman actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT katharinahennig actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT vanessafboura actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT raphaelvoituriez actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT mikaelcikarlsson actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT martialballand actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT anamarialennondumenil actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse AT paolopierobon actomyosindrivenforcepatterningcontrolsendocytosisattheimmunesynapse
_version_	1718382312395112448

Actomyosin-driven force patterning controls endocytosis at the immune synapse

Ejemplares similares