Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity
ABSTRACT We found that the relatively simple microbiota of young infants shifts predictably to a more mature anaerobic microbiota during infancy and the dynamics of this shift are influenced by environmental factors. In this longitudinal study of 75 infants, we demonstrate high interindividual vari...
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American Society for Microbiology
2015
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oai:doaj.org-article:153deb9191df4141ac58523108f6a9952021-11-15T15:41:19ZDynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity10.1128/mBio.02419-142150-7511https://doaj.org/article/153deb9191df4141ac58523108f6a9952015-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02419-14https://doaj.org/toc/2150-7511ABSTRACT We found that the relatively simple microbiota of young infants shifts predictably to a more mature anaerobic microbiota during infancy and the dynamics of this shift are influenced by environmental factors. In this longitudinal study of 75 infants, we demonstrate high interindividual variability within the normal range of birth outcomes, especially in the rate of microbiota progression. Most had acquired a microbiota profile high in Bifidobacterium and Collinsella by 6 months of age, but the time point of this acquisition was later in infants delivered by caesarean section and those born after a shorter duration of gestation. Independently of the delivery mode and gestation duration, infants who acquired a profile high in Bifidobacterium and Collinsella at a later age had lower adiposity at 18 months of age. IMPORTANCE This study shows that the acquisition of the early microbiota is strongly influenced by environmental factors such as the delivery mode and duration of gestation, even in healthy neonates. The composition of the early microbiota has been linked with long-lasting effects on health and disease. Here we show that the rate of acquisition of certain microbiota predicts adiposity at 18 months of age and so potentially the risk of later obesity.Shaillay DograOlga SakwinskaShu-E SohCatherine Ngom-BruWolfram M. BrückBernard BergerHarald BrüssowYung Seng LeeFabian YapYap-Seng ChongKeith M. GodfreyJoanna D. HolbrookAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 1 (2015) |
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DOAJ |
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Microbiology QR1-502 |
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Microbiology QR1-502 Shaillay Dogra Olga Sakwinska Shu-E Soh Catherine Ngom-Bru Wolfram M. Brück Bernard Berger Harald Brüssow Yung Seng Lee Fabian Yap Yap-Seng Chong Keith M. Godfrey Joanna D. Holbrook Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity |
| description |
ABSTRACT We found that the relatively simple microbiota of young infants shifts predictably to a more mature anaerobic microbiota during infancy and the dynamics of this shift are influenced by environmental factors. In this longitudinal study of 75 infants, we demonstrate high interindividual variability within the normal range of birth outcomes, especially in the rate of microbiota progression. Most had acquired a microbiota profile high in Bifidobacterium and Collinsella by 6 months of age, but the time point of this acquisition was later in infants delivered by caesarean section and those born after a shorter duration of gestation. Independently of the delivery mode and gestation duration, infants who acquired a profile high in Bifidobacterium and Collinsella at a later age had lower adiposity at 18 months of age. IMPORTANCE This study shows that the acquisition of the early microbiota is strongly influenced by environmental factors such as the delivery mode and duration of gestation, even in healthy neonates. The composition of the early microbiota has been linked with long-lasting effects on health and disease. Here we show that the rate of acquisition of certain microbiota predicts adiposity at 18 months of age and so potentially the risk of later obesity. |
| format |
article |
| author |
Shaillay Dogra Olga Sakwinska Shu-E Soh Catherine Ngom-Bru Wolfram M. Brück Bernard Berger Harald Brüssow Yung Seng Lee Fabian Yap Yap-Seng Chong Keith M. Godfrey Joanna D. Holbrook |
| author_facet |
Shaillay Dogra Olga Sakwinska Shu-E Soh Catherine Ngom-Bru Wolfram M. Brück Bernard Berger Harald Brüssow Yung Seng Lee Fabian Yap Yap-Seng Chong Keith M. Godfrey Joanna D. Holbrook |
| author_sort |
Shaillay Dogra |
| title |
Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity |
| title_short |
Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity |
| title_full |
Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity |
| title_fullStr |
Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity |
| title_full_unstemmed |
Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity |
| title_sort |
dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity |
| publisher |
American Society for Microbiology |
| publishDate |
2015 |
| url |
https://doaj.org/article/153deb9191df4141ac58523108f6a995 |
| work_keys_str_mv |
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1718427689559261184 |