Poor reproducibility of allergic rhinitis SNP associations.

Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daniel Nilsson, Anand Kumar Andiappan, Christer Halldén, Chew Fook Tim, Torbjörn Säll, De Yun Wang, Lars-Olaf Cardell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/153e40d670774e2fb2e84fcc6876f0d9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:153e40d670774e2fb2e84fcc6876f0d9
record_format	dspace
spelling	oai:doaj.org-article:153e40d670774e2fb2e84fcc6876f0d92021-11-18T07:59:35ZPoor reproducibility of allergic rhinitis SNP associations.1932-620310.1371/journal.pone.0053975https://doaj.org/article/153e40d670774e2fb2e84fcc6876f0d92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382861/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported.Daniel NilssonAnand Kumar AndiappanChrister HalldénChew Fook TimTorbjörn SällDe Yun WangLars-Olaf CardellPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53975 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Nilsson Anand Kumar Andiappan Christer Halldén Chew Fook Tim Torbjörn Säll De Yun Wang Lars-Olaf Cardell Poor reproducibility of allergic rhinitis SNP associations.
description	Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported.
format	article
author	Daniel Nilsson Anand Kumar Andiappan Christer Halldén Chew Fook Tim Torbjörn Säll De Yun Wang Lars-Olaf Cardell
author_facet	Daniel Nilsson Anand Kumar Andiappan Christer Halldén Chew Fook Tim Torbjörn Säll De Yun Wang Lars-Olaf Cardell
author_sort	Daniel Nilsson
title	Poor reproducibility of allergic rhinitis SNP associations.
title_short	Poor reproducibility of allergic rhinitis SNP associations.
title_full	Poor reproducibility of allergic rhinitis SNP associations.
title_fullStr	Poor reproducibility of allergic rhinitis SNP associations.
title_full_unstemmed	Poor reproducibility of allergic rhinitis SNP associations.
title_sort	poor reproducibility of allergic rhinitis snp associations.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/153e40d670774e2fb2e84fcc6876f0d9
work_keys_str_mv	AT danielnilsson poorreproducibilityofallergicrhinitissnpassociations AT anandkumarandiappan poorreproducibilityofallergicrhinitissnpassociations AT christerhallden poorreproducibilityofallergicrhinitissnpassociations AT chewfooktim poorreproducibilityofallergicrhinitissnpassociations AT torbjornsall poorreproducibilityofallergicrhinitissnpassociations AT deyunwang poorreproducibilityofallergicrhinitissnpassociations AT larsolafcardell poorreproducibilityofallergicrhinitissnpassociations
_version_	1718422650427015168

Poor reproducibility of allergic rhinitis SNP associations.

Ejemplares similares