Clinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: A multi-center study in Jiangsu Province
Asymptomatic SARS-CoV-2-infected individuals are thought to play major roles in virus transmission. This study aimed to analyze the characteristics of asymptomatic carriers with COVID-19 to control the spread of the virus. We retrospectively investigated the clinical characteristics of 648 consecuti...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Taylor & Francis Group
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/153f402d001b418eb3229f9cb556fb71 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:153f402d001b418eb3229f9cb556fb71 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:153f402d001b418eb3229f9cb556fb712021-11-17T14:21:59ZClinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: A multi-center study in Jiangsu Province2150-55942150-560810.1080/21505594.2020.1840122https://doaj.org/article/153f402d001b418eb3229f9cb556fb712020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1840122https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Asymptomatic SARS-CoV-2-infected individuals are thought to play major roles in virus transmission. This study aimed to analyze the characteristics of asymptomatic carriers with COVID-19 to control the spread of the virus. We retrospectively investigated the clinical characteristics of 648 consecutive subjects who were enrolled in the study and were divided into asymptomatic carriers, mild cases, ordinary cases, severe or critical cases, and evaluated their impact on disease severity by means of Spearman correlation and multiple regression analyses. Receiver operating characteristic curve analysis was conducted to determine the optimum cutoff levels of laboratory findings for diagnostic predictors of asymptomatic carriers of COVID-19. In our study, a total of 648 subjects on admission with a mean age of 45.61 y including 345 males and 303 females were enrolled in our study. The leukocyte, lymphocyte, eosinophil, platelet, C-reactive protein, interleukin-6, CD3+, CD4+, and CD8 + T lymphocyte levels, and the erythrocyte sedimentation rate differed significantly among the groups (all p ≤ 0.05). Disease severity was negatively associated with the CD3+ (r = −0.340; p < 0.001), CD4+ (r = −0.290; p = 0.001) and CD8+ (r = −0.322; p < 0.001) T lymphocyte levels. The significant diagnostic predictors of asymptomatic carriers of COVID-19 included the blood cell, cytokine, and T lymphocyte subset levels. Inflammation and immune response may play important roles in disease progression. Hence, the laboratory parameters identified should be considered in clinical practice, which provide new insights into the identification of asymptomatic individuals and the prevention of virus transmission.Jiaxin ChenTao HanMao HuangYi YangFutai ShangYishan ZhengWenjing ZhaoLiang LuoXudong HanAihua LinHongsheng ZhaoQin GuYi ShiJun LiXingxiang XuKexi LiuYijun DengEnzhi JiaQuan CaoTaylor & Francis Grouparticlenovel coronavirus disease-19covid-19severe acute respiratory syndrome coronavirus 2sars-cov-2asymptomatic carriersimmune responseinflammatory markerdisease severity of covid-19Infectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1557-1568 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
novel coronavirus disease-19 covid-19 severe acute respiratory syndrome coronavirus 2 sars-cov-2 asymptomatic carriers immune response inflammatory marker disease severity of covid-19 Infectious and parasitic diseases RC109-216 |
| spellingShingle |
novel coronavirus disease-19 covid-19 severe acute respiratory syndrome coronavirus 2 sars-cov-2 asymptomatic carriers immune response inflammatory marker disease severity of covid-19 Infectious and parasitic diseases RC109-216 Jiaxin Chen Tao Han Mao Huang Yi Yang Futai Shang Yishan Zheng Wenjing Zhao Liang Luo Xudong Han Aihua Lin Hongsheng Zhao Qin Gu Yi Shi Jun Li Xingxiang Xu Kexi Liu Yijun Deng Enzhi Jia Quan Cao Clinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: A multi-center study in Jiangsu Province |
| description |
Asymptomatic SARS-CoV-2-infected individuals are thought to play major roles in virus transmission. This study aimed to analyze the characteristics of asymptomatic carriers with COVID-19 to control the spread of the virus. We retrospectively investigated the clinical characteristics of 648 consecutive subjects who were enrolled in the study and were divided into asymptomatic carriers, mild cases, ordinary cases, severe or critical cases, and evaluated their impact on disease severity by means of Spearman correlation and multiple regression analyses. Receiver operating characteristic curve analysis was conducted to determine the optimum cutoff levels of laboratory findings for diagnostic predictors of asymptomatic carriers of COVID-19. In our study, a total of 648 subjects on admission with a mean age of 45.61 y including 345 males and 303 females were enrolled in our study. The leukocyte, lymphocyte, eosinophil, platelet, C-reactive protein, interleukin-6, CD3+, CD4+, and CD8 + T lymphocyte levels, and the erythrocyte sedimentation rate differed significantly among the groups (all p ≤ 0.05). Disease severity was negatively associated with the CD3+ (r = −0.340; p < 0.001), CD4+ (r = −0.290; p = 0.001) and CD8+ (r = −0.322; p < 0.001) T lymphocyte levels. The significant diagnostic predictors of asymptomatic carriers of COVID-19 included the blood cell, cytokine, and T lymphocyte subset levels. Inflammation and immune response may play important roles in disease progression. Hence, the laboratory parameters identified should be considered in clinical practice, which provide new insights into the identification of asymptomatic individuals and the prevention of virus transmission. |
| format |
article |
| author |
Jiaxin Chen Tao Han Mao Huang Yi Yang Futai Shang Yishan Zheng Wenjing Zhao Liang Luo Xudong Han Aihua Lin Hongsheng Zhao Qin Gu Yi Shi Jun Li Xingxiang Xu Kexi Liu Yijun Deng Enzhi Jia Quan Cao |
| author_facet |
Jiaxin Chen Tao Han Mao Huang Yi Yang Futai Shang Yishan Zheng Wenjing Zhao Liang Luo Xudong Han Aihua Lin Hongsheng Zhao Qin Gu Yi Shi Jun Li Xingxiang Xu Kexi Liu Yijun Deng Enzhi Jia Quan Cao |
| author_sort |
Jiaxin Chen |
| title |
Clinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: A multi-center study in Jiangsu Province |
| title_short |
Clinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: A multi-center study in Jiangsu Province |
| title_full |
Clinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: A multi-center study in Jiangsu Province |
| title_fullStr |
Clinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: A multi-center study in Jiangsu Province |
| title_full_unstemmed |
Clinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: A multi-center study in Jiangsu Province |
| title_sort |
clinical characteristics of asymptomatic carriers of novel coronavirus disease 2019: a multi-center study in jiangsu province |
| publisher |
Taylor & Francis Group |
| publishDate |
2020 |
| url |
https://doaj.org/article/153f402d001b418eb3229f9cb556fb71 |
| work_keys_str_mv |
AT jiaxinchen clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT taohan clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT maohuang clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT yiyang clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT futaishang clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT yishanzheng clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT wenjingzhao clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT liangluo clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT xudonghan clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT aihualin clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT hongshengzhao clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT qingu clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT yishi clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT junli clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT xingxiangxu clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT kexiliu clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT yijundeng clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT enzhijia clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince AT quancao clinicalcharacteristicsofasymptomaticcarriersofnovelcoronavirusdisease2019amulticenterstudyinjiangsuprovince |
| _version_ |
1718425397945696256 |