RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

RNA m6A methylation is known to be dysregulated in many cancers. Here, the authors show that m6A methylation of Snail mRNA regulates its translation with potential effects on epithelial mesenchymal transition.

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Autores principales: Xinyao Lin, Guoshi Chai, Yingmin Wu, Jiexin Li, Feng Chen, Jianzhao Liu, Guanzheng Luo, Jordi Tauler, Jun Du, Shuibin Lin, Chuan He, Hongsheng Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/15400780c3c04521ab71d2f2193c0bae
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Sumario:RNA m6A methylation is known to be dysregulated in many cancers. Here, the authors show that m6A methylation of Snail mRNA regulates its translation with potential effects on epithelial mesenchymal transition.