Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro

Summary: Terahertz (THz) frequency occupies a large portion of the electromagnetic spectrum that is between the infrared and microwave regions. Recent advances in THz application have stimulated interests regarding the biological effects within this frequency range. In the current study, we report t...

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Autores principales:	Xianghui Zhao, Ming Zhang, Yuming Liu, Haiying Liu, Keke Ren, Qian Xue, Haifeng Zhang, Na Zhi, Wenting Wang, Shengxi Wu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Medical Physics Radiation physics Neuroscience Science Q
Acceso en línea:	https://doaj.org/article/15440128a60e48ad928e7b5da6256bd7
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spelling	oai:doaj.org-article:15440128a60e48ad928e7b5da6256bd72021-12-04T04:35:34ZTerahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro2589-004210.1016/j.isci.2021.103485https://doaj.org/article/15440128a60e48ad928e7b5da6256bd72021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014565https://doaj.org/toc/2589-0042Summary: Terahertz (THz) frequency occupies a large portion of the electromagnetic spectrum that is between the infrared and microwave regions. Recent advances in THz application have stimulated interests regarding the biological effects within this frequency range. In the current study, we report that irradiation with a single-frequency THz laser on mice cortical neuron cultures increases excitatory synaptic transmission and neuronal firing activities. Microarray assay reveals gene expression dynamics after THz exposure, which is consistent with morphology and electrophysiology results. Besides, certain schedule of THz irradiation inhibits the proliferation of oligodendrocyte precursor cells (OPCs) and promotes OPC differentiation. Of note, the myelination process is enhanced after THz exposure. In summary, our observations suggest that THz irradiation can modulate the functions of different neuronal cells, with different sensitivity to THz. These results provide important understanding of the mechanisms that govern THz interactions with nervous systems and suggest THz wave as a new strategy for neuromodulation.Xianghui ZhaoMing ZhangYuming LiuHaiying LiuKeke RenQian XueHaifeng ZhangNa ZhiWenting WangShengxi WuElsevierarticleMedical PhysicsRadiation physicsNeuroscienceScienceQENiScience, Vol 24, Iss 12, Pp 103485- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical Physics Radiation physics Neuroscience Science Q
spellingShingle	Medical Physics Radiation physics Neuroscience Science Q Xianghui Zhao Ming Zhang Yuming Liu Haiying Liu Keke Ren Qian Xue Haifeng Zhang Na Zhi Wenting Wang Shengxi Wu Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro
description	Summary: Terahertz (THz) frequency occupies a large portion of the electromagnetic spectrum that is between the infrared and microwave regions. Recent advances in THz application have stimulated interests regarding the biological effects within this frequency range. In the current study, we report that irradiation with a single-frequency THz laser on mice cortical neuron cultures increases excitatory synaptic transmission and neuronal firing activities. Microarray assay reveals gene expression dynamics after THz exposure, which is consistent with morphology and electrophysiology results. Besides, certain schedule of THz irradiation inhibits the proliferation of oligodendrocyte precursor cells (OPCs) and promotes OPC differentiation. Of note, the myelination process is enhanced after THz exposure. In summary, our observations suggest that THz irradiation can modulate the functions of different neuronal cells, with different sensitivity to THz. These results provide important understanding of the mechanisms that govern THz interactions with nervous systems and suggest THz wave as a new strategy for neuromodulation.
format	article
author	Xianghui Zhao Ming Zhang Yuming Liu Haiying Liu Keke Ren Qian Xue Haifeng Zhang Na Zhi Wenting Wang Shengxi Wu
author_facet	Xianghui Zhao Ming Zhang Yuming Liu Haiying Liu Keke Ren Qian Xue Haifeng Zhang Na Zhi Wenting Wang Shengxi Wu
author_sort	Xianghui Zhao
title	Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro
title_short	Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro
title_full	Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro
title_fullStr	Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro
title_full_unstemmed	Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro
title_sort	terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/15440128a60e48ad928e7b5da6256bd7
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Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro

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