Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

Dysregulated liquid-liquid phase separation (LLPS) of proteins can facilitate aberrant phase transitions and lead to protein aggregation and disease. Here, authors demonstrate that 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid (bis-ANS) and similar compounds are potent biphasic modulators of p...

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Autores principales:	W. Michael Babinchak, Benjamin K. Dumm, Sarah Venus, Solomiia Boyko, Andrea A. Putnam, Eckhard Jankowsky, Witold K. Surewicz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1546e39d54c649998d644f397e8e1d40
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spelling	oai:doaj.org-article:1546e39d54c649998d644f397e8e1d402021-12-02T15:34:34ZSmall molecules as potent biphasic modulators of protein liquid-liquid phase separation10.1038/s41467-020-19211-z2041-1723https://doaj.org/article/1546e39d54c649998d644f397e8e1d402020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19211-zhttps://doaj.org/toc/2041-1723Dysregulated liquid-liquid phase separation (LLPS) of proteins can facilitate aberrant phase transitions and lead to protein aggregation and disease. Here, authors demonstrate that 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid (bis-ANS) and similar compounds are potent biphasic modulators of protein LLPS.W. Michael BabinchakBenjamin K. DummSarah VenusSolomiia BoykoAndrea A. PutnamEckhard JankowskyWitold K. SurewiczNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q W. Michael Babinchak Benjamin K. Dumm Sarah Venus Solomiia Boyko Andrea A. Putnam Eckhard Jankowsky Witold K. Surewicz Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
description	Dysregulated liquid-liquid phase separation (LLPS) of proteins can facilitate aberrant phase transitions and lead to protein aggregation and disease. Here, authors demonstrate that 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid (bis-ANS) and similar compounds are potent biphasic modulators of protein LLPS.
format	article
author	W. Michael Babinchak Benjamin K. Dumm Sarah Venus Solomiia Boyko Andrea A. Putnam Eckhard Jankowsky Witold K. Surewicz
author_facet	W. Michael Babinchak Benjamin K. Dumm Sarah Venus Solomiia Boyko Andrea A. Putnam Eckhard Jankowsky Witold K. Surewicz
author_sort	W. Michael Babinchak
title	Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
title_short	Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
title_full	Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
title_fullStr	Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
title_full_unstemmed	Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
title_sort	small molecules as potent biphasic modulators of protein liquid-liquid phase separation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1546e39d54c649998d644f397e8e1d40
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Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

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