Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1

Variations in the availability of nutritional resources in animals can trigger reversible adjustments, which in the short term are manifested as behavioral and physiological changes. Several of these responses are mediated by Sirt1, which acts as an energy status sensor governing a global genetic pr...

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Autores principales:	Isaac Peña-Villalobos, Fabiola A. Otárola, Bárbara S. Casas, Pablo Sabat, Verónica Palma
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	epigenetic fetal programming gluconeogenesis life history trait maternal gestational weight gain PPARs Physiology QP1-981
Acceso en línea:	https://doaj.org/article/154c85edce4b4a54972aac50e897d690
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spelling	oai:doaj.org-article:154c85edce4b4a54972aac50e897d6902021-12-02T17:18:11ZPerinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt11664-042X10.3389/fphys.2021.769444https://doaj.org/article/154c85edce4b4a54972aac50e897d6902021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.769444/fullhttps://doaj.org/toc/1664-042XVariations in the availability of nutritional resources in animals can trigger reversible adjustments, which in the short term are manifested as behavioral and physiological changes. Several of these responses are mediated by Sirt1, which acts as an energy status sensor governing a global genetic program to cope with changes in nutritional status. Growing evidence suggests a key role of the response of the perinatal environment to caloric restriction in the setup of physiological responses in adulthood. The existence of adaptive predictive responses has been proposed, which suggests that early nutrition could establish metabolic capacities suitable for future food-scarce environments. We evaluated how perinatal food deprivation and maternal gestational weight gain impact the transcriptional, physiological, and behavioral responses in mice, when acclimated to caloric restriction in adulthood. Our results show a strong predictive capacity of maternal weight and gestational weight gain, in the expression of Sirt1 and its downstream targets in the brain and liver, mitochondrial enzymatic activity in skeletal muscle, and exploratory behavior in offspring. We also observed differential responses of both lactation and gestational food restriction on gene expression, thermogenesis, organ masses, and behavior, in response to adult caloric restriction. We conclude that the early nutritional state could determine the magnitude of responses to food scarcity later in adulthood, mediated by the pivotal metabolic sensor Sirt1. Our results suggest that maternal gestational weight gain could be an important life history trait and could be used to predict features that improve the invasive capacity or adjustment to seasonal food scarcity of the offspring.Isaac Peña-VillalobosIsaac Peña-VillalobosFabiola A. OtárolaBárbara S. CasasPablo SabatPablo SabatVerónica PalmaFrontiers Media S.A.articleepigeneticfetal programminggluconeogenesislife history traitmaternal gestational weight gainPPARsPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigenetic fetal programming gluconeogenesis life history trait maternal gestational weight gain PPARs Physiology QP1-981
spellingShingle	epigenetic fetal programming gluconeogenesis life history trait maternal gestational weight gain PPARs Physiology QP1-981 Isaac Peña-Villalobos Isaac Peña-Villalobos Fabiola A. Otárola Bárbara S. Casas Pablo Sabat Pablo Sabat Verónica Palma Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
description	Variations in the availability of nutritional resources in animals can trigger reversible adjustments, which in the short term are manifested as behavioral and physiological changes. Several of these responses are mediated by Sirt1, which acts as an energy status sensor governing a global genetic program to cope with changes in nutritional status. Growing evidence suggests a key role of the response of the perinatal environment to caloric restriction in the setup of physiological responses in adulthood. The existence of adaptive predictive responses has been proposed, which suggests that early nutrition could establish metabolic capacities suitable for future food-scarce environments. We evaluated how perinatal food deprivation and maternal gestational weight gain impact the transcriptional, physiological, and behavioral responses in mice, when acclimated to caloric restriction in adulthood. Our results show a strong predictive capacity of maternal weight and gestational weight gain, in the expression of Sirt1 and its downstream targets in the brain and liver, mitochondrial enzymatic activity in skeletal muscle, and exploratory behavior in offspring. We also observed differential responses of both lactation and gestational food restriction on gene expression, thermogenesis, organ masses, and behavior, in response to adult caloric restriction. We conclude that the early nutritional state could determine the magnitude of responses to food scarcity later in adulthood, mediated by the pivotal metabolic sensor Sirt1. Our results suggest that maternal gestational weight gain could be an important life history trait and could be used to predict features that improve the invasive capacity or adjustment to seasonal food scarcity of the offspring.
format	article
author	Isaac Peña-Villalobos Isaac Peña-Villalobos Fabiola A. Otárola Bárbara S. Casas Pablo Sabat Pablo Sabat Verónica Palma
author_facet	Isaac Peña-Villalobos Isaac Peña-Villalobos Fabiola A. Otárola Bárbara S. Casas Pablo Sabat Pablo Sabat Verónica Palma
author_sort	Isaac Peña-Villalobos
title	Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_short	Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_full	Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_fullStr	Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_full_unstemmed	Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_sort	perinatal food deprivation modifies the caloric restriction response in adult mice through sirt1
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/154c85edce4b4a54972aac50e897d690
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Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1

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