Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA

MicroRNAs (miRNAs) are important non-coding, single-stranded RNAs possessing crucial regulating roles in human body. Therefore, miRNAs have received extensive attention from various disciplines as the aberrant expression of miRNAs are tightly related to different types of diseases. Furthermore, the...

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Autores principales:	Sze Shin Low, Daizong Ji, Wai Siong Chai, Jingjing Liu, Kuan Shiong Khoo, Sadegh Salmanpour, Fatemeh Karimi, Balakrishnan Deepanraj, Pau Loke Show
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanomaterial electrochemical biosensor MicroRNA signal amplification strategy Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/154d29c4a3354d38bcff6d20dab7074a
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spelling	oai:doaj.org-article:154d29c4a3354d38bcff6d20dab7074a2021-11-25T18:23:49ZRecent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA10.3390/mi121114092072-666Xhttps://doaj.org/article/154d29c4a3354d38bcff6d20dab7074a2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1409https://doaj.org/toc/2072-666XMicroRNAs (miRNAs) are important non-coding, single-stranded RNAs possessing crucial regulating roles in human body. Therefore, miRNAs have received extensive attention from various disciplines as the aberrant expression of miRNAs are tightly related to different types of diseases. Furthermore, the exceptional stability of miRNAs has presented them as biomarker with high specificity and sensitivity. However, small size, high sequence similarity, low abundance of miRNAs impose difficulty in their detection. Hence, it is of utmost importance to develop accurate and sensitive method for miRNA biosensing. Electrochemical biosensors have been demonstrated as promising solution for miRNA detection as they are highly sensitive, facile, and low-cost with ease of miniaturization. The incorporation of nanomaterials to electrochemical biosensor offers excellent prospects for converting biological recognition events to electronic signal for the development of biosensing platform with desired sensing properties due to their unique properties. This review introduces the signal amplification strategies employed in miRNA electrochemical biosensor and presents the feasibility of different strategies. The recent advances in nanomaterial-based electrochemical biosensor for the detection of miRNA were also discussed and summarized based on different types of miRNAs, opening new approaches in biological analysis and early disease diagnosis. Lastly, the challenges and future prospects are discussed.Sze Shin LowDaizong JiWai Siong ChaiJingjing LiuKuan Shiong KhooSadegh SalmanpourFatemeh KarimiBalakrishnan DeepanrajPau Loke ShowMDPI AGarticlenanomaterialelectrochemical biosensorMicroRNAsignal amplification strategyMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1409, p 1409 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomaterial electrochemical biosensor MicroRNA signal amplification strategy Mechanical engineering and machinery TJ1-1570
spellingShingle	nanomaterial electrochemical biosensor MicroRNA signal amplification strategy Mechanical engineering and machinery TJ1-1570 Sze Shin Low Daizong Ji Wai Siong Chai Jingjing Liu Kuan Shiong Khoo Sadegh Salmanpour Fatemeh Karimi Balakrishnan Deepanraj Pau Loke Show Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA
description	MicroRNAs (miRNAs) are important non-coding, single-stranded RNAs possessing crucial regulating roles in human body. Therefore, miRNAs have received extensive attention from various disciplines as the aberrant expression of miRNAs are tightly related to different types of diseases. Furthermore, the exceptional stability of miRNAs has presented them as biomarker with high specificity and sensitivity. However, small size, high sequence similarity, low abundance of miRNAs impose difficulty in their detection. Hence, it is of utmost importance to develop accurate and sensitive method for miRNA biosensing. Electrochemical biosensors have been demonstrated as promising solution for miRNA detection as they are highly sensitive, facile, and low-cost with ease of miniaturization. The incorporation of nanomaterials to electrochemical biosensor offers excellent prospects for converting biological recognition events to electronic signal for the development of biosensing platform with desired sensing properties due to their unique properties. This review introduces the signal amplification strategies employed in miRNA electrochemical biosensor and presents the feasibility of different strategies. The recent advances in nanomaterial-based electrochemical biosensor for the detection of miRNA were also discussed and summarized based on different types of miRNAs, opening new approaches in biological analysis and early disease diagnosis. Lastly, the challenges and future prospects are discussed.
format	article
author	Sze Shin Low Daizong Ji Wai Siong Chai Jingjing Liu Kuan Shiong Khoo Sadegh Salmanpour Fatemeh Karimi Balakrishnan Deepanraj Pau Loke Show
author_facet	Sze Shin Low Daizong Ji Wai Siong Chai Jingjing Liu Kuan Shiong Khoo Sadegh Salmanpour Fatemeh Karimi Balakrishnan Deepanraj Pau Loke Show
author_sort	Sze Shin Low
title	Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA
title_short	Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA
title_full	Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA
title_fullStr	Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA
title_full_unstemmed	Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA
title_sort	recent progress in nanomaterials modified electrochemical biosensors for the detection of microrna
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/154d29c4a3354d38bcff6d20dab7074a
work_keys_str_mv	AT szeshinlow recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna AT daizongji recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna AT waisiongchai recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna AT jingjingliu recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna AT kuanshiongkhoo recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna AT sadeghsalmanpour recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna AT fatemehkarimi recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna AT balakrishnandeepanraj recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna AT paulokeshow recentprogressinnanomaterialsmodifiedelectrochemicalbiosensorsforthedetectionofmicrorna
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Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA

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