High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming

Macrophages may polarize into different states with distinct regulatory functions for inflammation. Here the authors perform high-throughput in vitro screening of a library of ~4000 compounds to identify those with specific effects on human macrophage polarization, while RNAseq helps uncover the tar...

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Autores principales:	Guangan Hu, Yang Su, Byong Ha Kang, Zhongqi Fan, Ting Dong, Douglas R. Brown, Jaime Cheah, Karl Dane Wittrup, Jianzhu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1550a867bc7a4e05979cb68615b93744
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spelling	oai:doaj.org-article:1550a867bc7a4e05979cb68615b937442021-12-02T10:44:18ZHigh-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming10.1038/s41467-021-21066-x2041-1723https://doaj.org/article/1550a867bc7a4e05979cb68615b937442021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21066-xhttps://doaj.org/toc/2041-1723Macrophages may polarize into different states with distinct regulatory functions for inflammation. Here the authors perform high-throughput in vitro screening of a library of ~4000 compounds to identify those with specific effects on human macrophage polarization, while RNAseq helps uncover the targets and pathways mediating these effects.Guangan HuYang SuByong Ha KangZhongqi FanTing DongDouglas R. BrownJaime CheahKarl Dane WittrupJianzhu ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guangan Hu Yang Su Byong Ha Kang Zhongqi Fan Ting Dong Douglas R. Brown Jaime Cheah Karl Dane Wittrup Jianzhu Chen High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
description	Macrophages may polarize into different states with distinct regulatory functions for inflammation. Here the authors perform high-throughput in vitro screening of a library of ~4000 compounds to identify those with specific effects on human macrophage polarization, while RNAseq helps uncover the targets and pathways mediating these effects.
format	article
author	Guangan Hu Yang Su Byong Ha Kang Zhongqi Fan Ting Dong Douglas R. Brown Jaime Cheah Karl Dane Wittrup Jianzhu Chen
author_facet	Guangan Hu Yang Su Byong Ha Kang Zhongqi Fan Ting Dong Douglas R. Brown Jaime Cheah Karl Dane Wittrup Jianzhu Chen
author_sort	Guangan Hu
title	High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
title_short	High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
title_full	High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
title_fullStr	High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
title_full_unstemmed	High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
title_sort	high-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1550a867bc7a4e05979cb68615b93744
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High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming

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