Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms

Osteosarcoma is the most frequent type of bone cancer found in children and adolescents, and commonly arises in the metaphyseal region of tubular long bones. Standard therapeutic approaches, such as surgery, chemotherapy, and radiation therapy, are used in the management of osteosarcoma. In recent y...

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Autores principales:	Mohammad Tobeiha, Ali Rajabi, Arash Raisi, Mahshad Mohajeri, Soheil Mohammadi Yazdi, Amirhossein Davoodvandi, Fatemeh Aslanbeigi, MohamadSadegh Vaziri, Michael R. Hamblin, Hamed Mirzaei
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Osteosarcoma Bio-active compounds Natural products Signaling pathways Combination therapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/155147b4a25046edb9dc4ead40b5864b
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spelling	oai:doaj.org-article:155147b4a25046edb9dc4ead40b5864b2021-11-14T04:28:54ZPotential of natural products in osteosarcoma treatment: Focus on molecular mechanisms0753-332210.1016/j.biopha.2021.112257https://doaj.org/article/155147b4a25046edb9dc4ead40b5864b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010416https://doaj.org/toc/0753-3322Osteosarcoma is the most frequent type of bone cancer found in children and adolescents, and commonly arises in the metaphyseal region of tubular long bones. Standard therapeutic approaches, such as surgery, chemotherapy, and radiation therapy, are used in the management of osteosarcoma. In recent years, the mortality rate of osteosarcoma has decreased due to advances in treatment methods. Today, the scientific community is investigating the use of different naturally derived active principles against various types of cancer. Natural bioactive compounds can function against cancer cells in two ways. Firstly they can act as classical cytotoxic compounds by non-specifically affecting macromolecules, such as DNA, enzymes, and microtubules, which are also expressed in normal proliferating cells, but to a greater extent by cancer cells. Secondly, they can act against oncogenic signal transduction pathways, many of which are activated in cancer cells. Some bioactive plant-derived agents are gaining increasing attention because of their anti-cancer properties. Moreover, some naturally-derived compounds can significantly promote the effectiveness of standard chemotherapy drugs, and in certain cases are able to ameliorate drug-induced adverse effects caused by chemotherapy. In the present review we summarize the effects of various naturally-occurring bioactive compounds against osteosarcoma.Mohammad TobeihaAli RajabiArash RaisiMahshad MohajeriSoheil Mohammadi YazdiAmirhossein DavoodvandiFatemeh AslanbeigiMohamadSadegh VaziriMichael R. HamblinHamed MirzaeiElsevierarticleOsteosarcomaBio-active compoundsNatural productsSignaling pathwaysCombination therapyTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112257- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Osteosarcoma Bio-active compounds Natural products Signaling pathways Combination therapy Therapeutics. Pharmacology RM1-950
spellingShingle	Osteosarcoma Bio-active compounds Natural products Signaling pathways Combination therapy Therapeutics. Pharmacology RM1-950 Mohammad Tobeiha Ali Rajabi Arash Raisi Mahshad Mohajeri Soheil Mohammadi Yazdi Amirhossein Davoodvandi Fatemeh Aslanbeigi MohamadSadegh Vaziri Michael R. Hamblin Hamed Mirzaei Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms
description	Osteosarcoma is the most frequent type of bone cancer found in children and adolescents, and commonly arises in the metaphyseal region of tubular long bones. Standard therapeutic approaches, such as surgery, chemotherapy, and radiation therapy, are used in the management of osteosarcoma. In recent years, the mortality rate of osteosarcoma has decreased due to advances in treatment methods. Today, the scientific community is investigating the use of different naturally derived active principles against various types of cancer. Natural bioactive compounds can function against cancer cells in two ways. Firstly they can act as classical cytotoxic compounds by non-specifically affecting macromolecules, such as DNA, enzymes, and microtubules, which are also expressed in normal proliferating cells, but to a greater extent by cancer cells. Secondly, they can act against oncogenic signal transduction pathways, many of which are activated in cancer cells. Some bioactive plant-derived agents are gaining increasing attention because of their anti-cancer properties. Moreover, some naturally-derived compounds can significantly promote the effectiveness of standard chemotherapy drugs, and in certain cases are able to ameliorate drug-induced adverse effects caused by chemotherapy. In the present review we summarize the effects of various naturally-occurring bioactive compounds against osteosarcoma.
format	article
author	Mohammad Tobeiha Ali Rajabi Arash Raisi Mahshad Mohajeri Soheil Mohammadi Yazdi Amirhossein Davoodvandi Fatemeh Aslanbeigi MohamadSadegh Vaziri Michael R. Hamblin Hamed Mirzaei
author_facet	Mohammad Tobeiha Ali Rajabi Arash Raisi Mahshad Mohajeri Soheil Mohammadi Yazdi Amirhossein Davoodvandi Fatemeh Aslanbeigi MohamadSadegh Vaziri Michael R. Hamblin Hamed Mirzaei
author_sort	Mohammad Tobeiha
title	Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms
title_short	Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms
title_full	Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms
title_fullStr	Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms
title_full_unstemmed	Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms
title_sort	potential of natural products in osteosarcoma treatment: focus on molecular mechanisms
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/155147b4a25046edb9dc4ead40b5864b
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Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms

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