Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials

Atherosclerosis is a chronic inflammatory disorder of the vasculature where cholesterol accumulates in the arterial wall stimulating infiltration of immune cells. This plays an important role in plaque formation, as well as complications caused by its build up. Pro-inflammatory cytokines and chemoki...

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Autor principal:	Alberto J Lorenzatti
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/1555b55142bf407fab46478523949ebd
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spelling	oai:doaj.org-article:1555b55142bf407fab46478523949ebd2021-12-04T16:04:22ZAnti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials10.15420/ecr.2020.511758-37641758-3756https://doaj.org/article/1555b55142bf407fab46478523949ebd2021-04-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2020.51https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Atherosclerosis is a chronic inflammatory disorder of the vasculature where cholesterol accumulates in the arterial wall stimulating infiltration of immune cells. This plays an important role in plaque formation, as well as complications caused by its build up. Pro-inflammatory cytokines and chemokines are implicated throughout the progression of the disease and different therapies that aim to resolve this chronic inflammation, reduce cardiovascular (CV) events and improve clinical outcomes have been tested. The results from the pivotal CANTOS trial show that targeting the pro-inflammatory cytokine IL-1β successfully reduces the incidence of secondary CV events. This review briefly assesses the role of inflammation in atherosclerosis, providing a picture of the multiple players involved in the process and offering a perspective on targeting inflammation to prevent atherosclerotic CV events, as well as focusing on the results of the latest Phase III clinical trials.Alberto J LorenzattiRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 16, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Alberto J Lorenzatti Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
description	Atherosclerosis is a chronic inflammatory disorder of the vasculature where cholesterol accumulates in the arterial wall stimulating infiltration of immune cells. This plays an important role in plaque formation, as well as complications caused by its build up. Pro-inflammatory cytokines and chemokines are implicated throughout the progression of the disease and different therapies that aim to resolve this chronic inflammation, reduce cardiovascular (CV) events and improve clinical outcomes have been tested. The results from the pivotal CANTOS trial show that targeting the pro-inflammatory cytokine IL-1β successfully reduces the incidence of secondary CV events. This review briefly assesses the role of inflammation in atherosclerosis, providing a picture of the multiple players involved in the process and offering a perspective on targeting inflammation to prevent atherosclerotic CV events, as well as focusing on the results of the latest Phase III clinical trials.
format	article
author	Alberto J Lorenzatti
author_facet	Alberto J Lorenzatti
author_sort	Alberto J Lorenzatti
title	Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
title_short	Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
title_full	Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
title_fullStr	Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
title_full_unstemmed	Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials
title_sort	anti-inflammatory treatment and cardiovascular outcomes: results of clinical trials
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/1555b55142bf407fab46478523949ebd
work_keys_str_mv	AT albertojlorenzatti antiinflammatorytreatmentandcardiovascularoutcomesresultsofclinicaltrials
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Anti-inflammatory Treatment and Cardiovascular Outcomes: Results of Clinical Trials

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