Microstructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires

The MgCa0.7 alloy may be a promising material for biodegradable surgical wires. In this paper, the technology for producing surgical wires from this alloy has been developed, based both on finite element modelling and experimental study. In particular, the extrusion and hot-drawing effects on the me...

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Autores principales:	Andrij Milenin, Mirosław Wróbel, Piotr Kustra, Dorota Byrska-Wójcik, Joanna Sulej-Chojnacka, Bartłomiej Płonka, Krzysztof Łukowicz, Karolina Truchan, Anna Osyczka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biodegradable surgical wire magnesium alloys in-vitro bio-corrosion cytotoxicity anti-tumour activity Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/1555ed6647cc446eb7fd55b9d6182071
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spelling	oai:doaj.org-article:1555ed6647cc446eb7fd55b9d61820712021-11-11T18:11:09ZMicrostructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires10.3390/ma142166731996-1944https://doaj.org/article/1555ed6647cc446eb7fd55b9d61820712021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6673https://doaj.org/toc/1996-1944The MgCa0.7 alloy may be a promising material for biodegradable surgical wires. In this paper, the technology for producing surgical wires from this alloy has been developed, based both on finite element modelling and experimental study. In particular, the extrusion and hot-drawing effects on the mechanical properties, microstructures, in-vitro rates of biocorrosion, and cytotoxicity to human cancer cells (SaOS-2) and healthy (hPDL) ones, have been determined. An approximately 30–40% increase in corrosion rate due to increasing hot-drawing temperature was observed. An effect of hot-drawing temperature on cytotoxicity was also found. Notably, at various stages of the final wires’ production, the MgCa0.7 alloy became toxic to cancer cells. This cytotoxicity depended on the alloys’ processing parameters and was maximal for the as-extruded rod and for the wires immediately after hot drawing at 440 °C. Thus, the careful selection of processing parameters makes it possible to obtain a product that is not only a promising candidate for biodegradable surgical wires, but one which also has intrinsic bioactive properties that produce antitumor activity.Andrij MileninMirosław WróbelPiotr KustraDorota Byrska-WójcikJoanna Sulej-ChojnackaBartłomiej PłonkaKrzysztof ŁukowiczKarolina TruchanAnna OsyczkaMDPI AGarticlebiodegradable surgical wiremagnesium alloysin-vitro bio-corrosioncytotoxicityanti-tumour activityTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6673, p 6673 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biodegradable surgical wire magnesium alloys in-vitro bio-corrosion cytotoxicity anti-tumour activity Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	biodegradable surgical wire magnesium alloys in-vitro bio-corrosion cytotoxicity anti-tumour activity Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Andrij Milenin Mirosław Wróbel Piotr Kustra Dorota Byrska-Wójcik Joanna Sulej-Chojnacka Bartłomiej Płonka Krzysztof Łukowicz Karolina Truchan Anna Osyczka Microstructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires
description	The MgCa0.7 alloy may be a promising material for biodegradable surgical wires. In this paper, the technology for producing surgical wires from this alloy has been developed, based both on finite element modelling and experimental study. In particular, the extrusion and hot-drawing effects on the mechanical properties, microstructures, in-vitro rates of biocorrosion, and cytotoxicity to human cancer cells (SaOS-2) and healthy (hPDL) ones, have been determined. An approximately 30–40% increase in corrosion rate due to increasing hot-drawing temperature was observed. An effect of hot-drawing temperature on cytotoxicity was also found. Notably, at various stages of the final wires’ production, the MgCa0.7 alloy became toxic to cancer cells. This cytotoxicity depended on the alloys’ processing parameters and was maximal for the as-extruded rod and for the wires immediately after hot drawing at 440 °C. Thus, the careful selection of processing parameters makes it possible to obtain a product that is not only a promising candidate for biodegradable surgical wires, but one which also has intrinsic bioactive properties that produce antitumor activity.
format	article
author	Andrij Milenin Mirosław Wróbel Piotr Kustra Dorota Byrska-Wójcik Joanna Sulej-Chojnacka Bartłomiej Płonka Krzysztof Łukowicz Karolina Truchan Anna Osyczka
author_facet	Andrij Milenin Mirosław Wróbel Piotr Kustra Dorota Byrska-Wójcik Joanna Sulej-Chojnacka Bartłomiej Płonka Krzysztof Łukowicz Karolina Truchan Anna Osyczka
author_sort	Andrij Milenin
title	Microstructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires
title_short	Microstructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires
title_full	Microstructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires
title_fullStr	Microstructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires
title_full_unstemmed	Microstructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires
title_sort	microstructure and in vitro evaluation of extruded and hot drawn alloy mgca0.7 for biodegradable surgical wires
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1555ed6647cc446eb7fd55b9d6182071
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Microstructure and In Vitro Evaluation of Extruded and Hot Drawn Alloy MgCa0.7 for Biodegradable Surgical Wires

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