SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling

Macrophages survey their surroundings using macropinocytosis, but its regulation is unclear. Here, the authors report that SLIT2, a known inhibitor of Rac GTPases, is an endogenous inhibitor of macropinocytosis, and that SLIT2 limits the uptake of NOD2 ligands into immune cells and subsequent releas...

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Autores principales:	Vikrant K. Bhosle, Tapas Mukherjee, Yi-Wei Huang, Sajedabanu Patel, Bo Wen (Frank) Pang, Guang-Ying Liu, Michael Glogauer, Jane Y. Wu, Dana J. Philpott, Sergio Grinstein, Lisa A. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/155a4ff4159741ce9f07b911d6e0af13
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spelling	oai:doaj.org-article:155a4ff4159741ce9f07b911d6e0af132021-12-02T18:00:09ZSLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling10.1038/s41467-020-17651-12041-1723https://doaj.org/article/155a4ff4159741ce9f07b911d6e0af132020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17651-1https://doaj.org/toc/2041-1723Macrophages survey their surroundings using macropinocytosis, but its regulation is unclear. Here, the authors report that SLIT2, a known inhibitor of Rac GTPases, is an endogenous inhibitor of macropinocytosis, and that SLIT2 limits the uptake of NOD2 ligands into immune cells and subsequent release of the inflammatory chemokine, CXCL1, in vivo.Vikrant K. BhosleTapas MukherjeeYi-Wei HuangSajedabanu PatelBo Wen (Frank) PangGuang-Ying LiuMichael GlogauerJane Y. WuDana J. PhilpottSergio GrinsteinLisa A. RobinsonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vikrant K. Bhosle Tapas Mukherjee Yi-Wei Huang Sajedabanu Patel Bo Wen (Frank) Pang Guang-Ying Liu Michael Glogauer Jane Y. Wu Dana J. Philpott Sergio Grinstein Lisa A. Robinson SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling
description	Macrophages survey their surroundings using macropinocytosis, but its regulation is unclear. Here, the authors report that SLIT2, a known inhibitor of Rac GTPases, is an endogenous inhibitor of macropinocytosis, and that SLIT2 limits the uptake of NOD2 ligands into immune cells and subsequent release of the inflammatory chemokine, CXCL1, in vivo.
format	article
author	Vikrant K. Bhosle Tapas Mukherjee Yi-Wei Huang Sajedabanu Patel Bo Wen (Frank) Pang Guang-Ying Liu Michael Glogauer Jane Y. Wu Dana J. Philpott Sergio Grinstein Lisa A. Robinson
author_facet	Vikrant K. Bhosle Tapas Mukherjee Yi-Wei Huang Sajedabanu Patel Bo Wen (Frank) Pang Guang-Ying Liu Michael Glogauer Jane Y. Wu Dana J. Philpott Sergio Grinstein Lisa A. Robinson
author_sort	Vikrant K. Bhosle
title	SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling
title_short	SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling
title_full	SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling
title_fullStr	SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling
title_full_unstemmed	SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling
title_sort	slit2/robo1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/155a4ff4159741ce9f07b911d6e0af13
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SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling

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