SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling

Macrophages survey their surroundings using macropinocytosis, but its regulation is unclear. Here, the authors report that SLIT2, a known inhibitor of Rac GTPases, is an endogenous inhibitor of macropinocytosis, and that SLIT2 limits the uptake of NOD2 ligands into immune cells and subsequent releas...

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Autores principales: Vikrant K. Bhosle, Tapas Mukherjee, Yi-Wei Huang, Sajedabanu Patel, Bo Wen (Frank) Pang, Guang-Ying Liu, Michael Glogauer, Jane Y. Wu, Dana J. Philpott, Sergio Grinstein, Lisa A. Robinson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/155a4ff4159741ce9f07b911d6e0af13
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