Oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis

Case summary An 11-year-old female spayed domestic medium-hair cat presented for dental prophylaxis, at which time no oral mass was appreciated. Fifteen days after a dental cleaning, a mass expanding the oral mucosa of the rostral mandible was identified. An incisional biopsy revealed that the oral...

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Autores principales:	Stephani L Ruppert, Sylvia H Ferguson, Jason D Struthers, Teela L Jones
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/155a5431fa124f84a00ea120f4be577d
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spelling	oai:doaj.org-article:155a5431fa124f84a00ea120f4be577d2021-11-09T22:34:02ZOral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis2055-116910.1177/20551169211058044https://doaj.org/article/155a5431fa124f84a00ea120f4be577d2021-11-01T00:00:00Zhttps://doi.org/10.1177/20551169211058044https://doaj.org/toc/2055-1169Case summary An 11-year-old female spayed domestic medium-hair cat presented for dental prophylaxis, at which time no oral mass was appreciated. Fifteen days after a dental cleaning, a mass expanding the oral mucosa of the rostral mandible was identified. An incisional biopsy revealed that the oral mucosa was infiltrated by neoplastic round-to-spindloid mesenchymal cells arranged in streams and small, dense aggregates consistent with an undifferentiated sarcoma. The patient was managed medically for approximately 6 months following the diagnosis, but, owing to declining health, euthanasia was elected and a post-mortem examination was performed. On post-mortem examination, the previously described neoplastic cells were infiltrating the rostral mandible and had metastasized to the right submandibular lymph node. Immunohistochemistry performed during the postmortem examination found that neoplastic cells were positive for Iba-1, CD18 and CD204, and negative for MUM-1, S100, Melan-A and E-cadherin, favoring a diagnosis of oral histiocytic sarcoma. Although recently recognized in cats, feline oral histiocytic sarcoma is rare, the tumor’s immunohistochemical profile is unstandardized, and the tumor’s behavior and prognosis are unclear. The diagnosis is challenging if small incisional biopsies are submitted and the neoplasm is poorly differentiated. This case report discusses the clinical, macroscopic, microscopic and immunohistochemical features of oral histiocytic sarcoma in a cat with mandibular invasion and submandibular lymph node metastasis. Relevance and novel information Feline primary oral histiocytic sarcoma is rare and tumor behavior and prognosis are unclear. This report broadens the immunohistochemical features of the tumor and recognizes mandibular invasion and submandibular lymph node metastasis.Stephani L RuppertSylvia H FergusonJason D StruthersTeela L JonesSAGE PublishingarticleVeterinary medicineSF600-1100ENJournal of Feline Medicine and Surgery Open Reports, Vol 7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Stephani L Ruppert Sylvia H Ferguson Jason D Struthers Teela L Jones Oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis
description	Case summary An 11-year-old female spayed domestic medium-hair cat presented for dental prophylaxis, at which time no oral mass was appreciated. Fifteen days after a dental cleaning, a mass expanding the oral mucosa of the rostral mandible was identified. An incisional biopsy revealed that the oral mucosa was infiltrated by neoplastic round-to-spindloid mesenchymal cells arranged in streams and small, dense aggregates consistent with an undifferentiated sarcoma. The patient was managed medically for approximately 6 months following the diagnosis, but, owing to declining health, euthanasia was elected and a post-mortem examination was performed. On post-mortem examination, the previously described neoplastic cells were infiltrating the rostral mandible and had metastasized to the right submandibular lymph node. Immunohistochemistry performed during the postmortem examination found that neoplastic cells were positive for Iba-1, CD18 and CD204, and negative for MUM-1, S100, Melan-A and E-cadherin, favoring a diagnosis of oral histiocytic sarcoma. Although recently recognized in cats, feline oral histiocytic sarcoma is rare, the tumor’s immunohistochemical profile is unstandardized, and the tumor’s behavior and prognosis are unclear. The diagnosis is challenging if small incisional biopsies are submitted and the neoplasm is poorly differentiated. This case report discusses the clinical, macroscopic, microscopic and immunohistochemical features of oral histiocytic sarcoma in a cat with mandibular invasion and submandibular lymph node metastasis. Relevance and novel information Feline primary oral histiocytic sarcoma is rare and tumor behavior and prognosis are unclear. This report broadens the immunohistochemical features of the tumor and recognizes mandibular invasion and submandibular lymph node metastasis.
format	article
author	Stephani L Ruppert Sylvia H Ferguson Jason D Struthers Teela L Jones
author_facet	Stephani L Ruppert Sylvia H Ferguson Jason D Struthers Teela L Jones
author_sort	Stephani L Ruppert
title	Oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis
title_short	Oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis
title_full	Oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis
title_fullStr	Oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis
title_full_unstemmed	Oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis
title_sort	oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/155a5431fa124f84a00ea120f4be577d
work_keys_str_mv	AT stephanilruppert oralhistiocyticsarcomainacatwithmandibularinvasionandregionallymphnodemetastasis AT sylviahferguson oralhistiocyticsarcomainacatwithmandibularinvasionandregionallymphnodemetastasis AT jasondstruthers oralhistiocyticsarcomainacatwithmandibularinvasionandregionallymphnodemetastasis AT teelaljones oralhistiocyticsarcomainacatwithmandibularinvasionandregionallymphnodemetastasis
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Oral histiocytic sarcoma in a cat with mandibular invasion and regional lymph node metastasis

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