Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women

Abstract Background Radiotherapy (RT) might lead to atherosclerotic plaque buildup and coronary artery stenosis of breast cancer (BC) survivors, and coronary artery calcium (CAC) might be a sign of preclinical atherosclerosis. This study explores possible determinants affecting the acceleration of C...

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Autores principales:	Yu-Hsuan Lai, Helen H. W. Chen, Yi-Shan Tsai
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Coronary artery calcium Breast cancer CAC percentiles Adjuvant radiotherapy Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/155a7c23ace34fa4bb563f7fd53c7431
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spelling	oai:doaj.org-article:155a7c23ace34fa4bb563f7fd53c74312021-11-08T10:45:00ZAccelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women10.1186/s13014-021-01936-w1748-717Xhttps://doaj.org/article/155a7c23ace34fa4bb563f7fd53c74312021-11-01T00:00:00Zhttps://doi.org/10.1186/s13014-021-01936-whttps://doaj.org/toc/1748-717XAbstract Background Radiotherapy (RT) might lead to atherosclerotic plaque buildup and coronary artery stenosis of breast cancer (BC) survivors, and coronary artery calcium (CAC) might be a sign of preclinical atherosclerosis. This study explores possible determinants affecting the acceleration of CAC burden in BC patients after adjuvant RT. Methods Female BC patients receiving adjuvant RT from 2002 to 2010 were included. All patients received noncontrast computed tomography (NCCT) of thorax before and after adjuvant RT. Their CAC burden was compared with healthy controls from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. The progression of the CAC burden was manifested by the increment of CAC percentiles (%CACinc). Results Ninety-four patients, including both left- and right-side BC, were enrolled in this study. From undergoing the first to second NCCT, the %CACinc in BC patients significantly increased rather than non-BC women. In addition, the %CACinc was significantly higher in left-side than right-side BC patients (p < 0.05), and significant differences in most heart outcomes were found between the two groups. Besides, the lower the mean right coronary artery (RCA) dose, the lower the risks of CAC percentiles increase ≥ 50% after adjusting the disease's laterality. Conclusions A significantly higher accelerated CAC burden in BC patients than non-BC women represents that BC could affect accelerated CAC. A higher risk of accelerated CAC burden was found in left-side than right-side BC patients after adjuvant RT. A decrease of the mean RCA dose could reduce more than 50% of the risk of accelerated CAC burden in BC patients.Yu-Hsuan LaiHelen H. W. ChenYi-Shan TsaiBMCarticleCoronary artery calciumBreast cancerCAC percentilesAdjuvant radiotherapyMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENRadiation Oncology, Vol 16, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coronary artery calcium Breast cancer CAC percentiles Adjuvant radiotherapy Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Coronary artery calcium Breast cancer CAC percentiles Adjuvant radiotherapy Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yu-Hsuan Lai Helen H. W. Chen Yi-Shan Tsai Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women
description	Abstract Background Radiotherapy (RT) might lead to atherosclerotic plaque buildup and coronary artery stenosis of breast cancer (BC) survivors, and coronary artery calcium (CAC) might be a sign of preclinical atherosclerosis. This study explores possible determinants affecting the acceleration of CAC burden in BC patients after adjuvant RT. Methods Female BC patients receiving adjuvant RT from 2002 to 2010 were included. All patients received noncontrast computed tomography (NCCT) of thorax before and after adjuvant RT. Their CAC burden was compared with healthy controls from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. The progression of the CAC burden was manifested by the increment of CAC percentiles (%CACinc). Results Ninety-four patients, including both left- and right-side BC, were enrolled in this study. From undergoing the first to second NCCT, the %CACinc in BC patients significantly increased rather than non-BC women. In addition, the %CACinc was significantly higher in left-side than right-side BC patients (p < 0.05), and significant differences in most heart outcomes were found between the two groups. Besides, the lower the mean right coronary artery (RCA) dose, the lower the risks of CAC percentiles increase ≥ 50% after adjusting the disease's laterality. Conclusions A significantly higher accelerated CAC burden in BC patients than non-BC women represents that BC could affect accelerated CAC. A higher risk of accelerated CAC burden was found in left-side than right-side BC patients after adjuvant RT. A decrease of the mean RCA dose could reduce more than 50% of the risk of accelerated CAC burden in BC patients.
format	article
author	Yu-Hsuan Lai Helen H. W. Chen Yi-Shan Tsai
author_facet	Yu-Hsuan Lai Helen H. W. Chen Yi-Shan Tsai
author_sort	Yu-Hsuan Lai
title	Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women
title_short	Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women
title_full	Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women
title_fullStr	Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women
title_full_unstemmed	Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women
title_sort	accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women
publisher	BMC
publishDate	2021
url	https://doaj.org/article/155a7c23ace34fa4bb563f7fd53c7431
work_keys_str_mv	AT yuhsuanlai acceleratedcoronarycalciumburdeninbreastcancerpatientsafterradiotherapyacomparisonwithageandracematchedhealthywomen AT helenhwchen acceleratedcoronarycalciumburdeninbreastcancerpatientsafterradiotherapyacomparisonwithageandracematchedhealthywomen AT yishantsai acceleratedcoronarycalciumburdeninbreastcancerpatientsafterradiotherapyacomparisonwithageandracematchedhealthywomen
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Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women

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