Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity

Abstract Subcortical volumetric changes in major depressive disorder (MDD) have been purported to underlie depressive symptomology, however, the evidence to date remains inconsistent. Here, we investigated limbic volumes in MDD, utilizing high-resolution structural images to allow segmentation of th...

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Autores principales:	S. S. G. Brown, J. W. Rutland, G. Verma, R. E. Feldman, J. Alper, M. Schneider, B. N. Delman, J. M. Murrough, P. Balchandani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/155c8458ecc34dc4bfe3ba30414b4acb
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spelling	oai:doaj.org-article:155c8458ecc34dc4bfe3ba30414b4acb2021-12-02T15:09:46ZStructural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity10.1038/s41598-019-46687-72045-2322https://doaj.org/article/155c8458ecc34dc4bfe3ba30414b4acb2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46687-7https://doaj.org/toc/2045-2322Abstract Subcortical volumetric changes in major depressive disorder (MDD) have been purported to underlie depressive symptomology, however, the evidence to date remains inconsistent. Here, we investigated limbic volumes in MDD, utilizing high-resolution structural images to allow segmentation of the hippocampus and amygdala into their constituent substructures. Twenty-four MDD patients and twenty matched controls underwent structural MRI at 7T field strength. All participants completed the Montgomery-Asberg Depression Rating Scale (MADRS) to quantify depressive symptomology. For the MDD group, volumes of the amygdala right lateral nucleus (p = 0.05, r 2 = 0.24), left cortical nucleus (p = 0.032, r 2 = 0.35), left accessory basal nucleus (p = 0.04, r 2 = 0.28) and bilateral corticoamygdaloid transition area (right hemisphere p = 0.032, r 2 = 0.38, left hemisphere p = 0.032, r 2 = 0.35) each displayed significant negative associations with MDD severity. The bilateral centrocortical (right hemisphere p = 0.032, r 2 = 0.31, left hemisphere p = 0.032, r 2 = 0.32) and right basolateral complexes (p = 0.05, r 2 = 0.24) also displayed significant negative relationships with depressive symptoms. Using high-field strength MRI, we report the novel finding that MDD severity is consistently negatively associated with amygdala nuclei, linking volumetric reductions with worsening depressive symptoms.S. S. G. BrownJ. W. RutlandG. VermaR. E. FeldmanJ. AlperM. SchneiderB. N. DelmanJ. M. MurroughP. BalchandaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. S. G. Brown J. W. Rutland G. Verma R. E. Feldman J. Alper M. Schneider B. N. Delman J. M. Murrough P. Balchandani Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity
description	Abstract Subcortical volumetric changes in major depressive disorder (MDD) have been purported to underlie depressive symptomology, however, the evidence to date remains inconsistent. Here, we investigated limbic volumes in MDD, utilizing high-resolution structural images to allow segmentation of the hippocampus and amygdala into their constituent substructures. Twenty-four MDD patients and twenty matched controls underwent structural MRI at 7T field strength. All participants completed the Montgomery-Asberg Depression Rating Scale (MADRS) to quantify depressive symptomology. For the MDD group, volumes of the amygdala right lateral nucleus (p = 0.05, r 2 = 0.24), left cortical nucleus (p = 0.032, r 2 = 0.35), left accessory basal nucleus (p = 0.04, r 2 = 0.28) and bilateral corticoamygdaloid transition area (right hemisphere p = 0.032, r 2 = 0.38, left hemisphere p = 0.032, r 2 = 0.35) each displayed significant negative associations with MDD severity. The bilateral centrocortical (right hemisphere p = 0.032, r 2 = 0.31, left hemisphere p = 0.032, r 2 = 0.32) and right basolateral complexes (p = 0.05, r 2 = 0.24) also displayed significant negative relationships with depressive symptoms. Using high-field strength MRI, we report the novel finding that MDD severity is consistently negatively associated with amygdala nuclei, linking volumetric reductions with worsening depressive symptoms.
format	article
author	S. S. G. Brown J. W. Rutland G. Verma R. E. Feldman J. Alper M. Schneider B. N. Delman J. M. Murrough P. Balchandani
author_facet	S. S. G. Brown J. W. Rutland G. Verma R. E. Feldman J. Alper M. Schneider B. N. Delman J. M. Murrough P. Balchandani
author_sort	S. S. G. Brown
title	Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity
title_short	Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity
title_full	Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity
title_fullStr	Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity
title_full_unstemmed	Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity
title_sort	structural mri at 7t reveals amygdala nuclei and hippocampal subfield volumetric association with major depressive disorder symptom severity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/155c8458ecc34dc4bfe3ba30414b4acb
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Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity

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