WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation
Human WNT10A mutations are associated with dental defects and adult onset ectodermal dysplasia. Xuet al. show that WNT10A-activated ß-catenin plays dual roles in adult epithelial progenitor proliferation and differentiation by complexing with KLF4 in differentiating, but not proliferating, cells.
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Nature Portfolio
2017
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oai:doaj.org-article:155ddb06076c415fa01075d340f6d7382021-12-02T15:38:31ZWNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation10.1038/ncomms153972041-1723https://doaj.org/article/155ddb06076c415fa01075d340f6d7382017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15397https://doaj.org/toc/2041-1723Human WNT10A mutations are associated with dental defects and adult onset ectodermal dysplasia. Xuet al. show that WNT10A-activated ß-catenin plays dual roles in adult epithelial progenitor proliferation and differentiation by complexing with KLF4 in differentiating, but not proliferating, cells.Mingang XuJeremy HorrellMelinda SnitowJiawei CuiHeather GochnauerCamille M. SyrettStaci KallishJohn T. SeykoraFei LiuDany GaillardJonathan P. KatzKlaus H. KaestnerBrooke LevinCorinne MansfieldJennifer E. DouglasBeverly J. CowartMichael TordoffFang LiuXuming ZhuLinda A. BarlowAdam I. RubinJohn A. McGrathEdward E. MorriseyEmily Y. ChuSarah E. MillarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-21 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mingang Xu Jeremy Horrell Melinda Snitow Jiawei Cui Heather Gochnauer Camille M. Syrett Staci Kallish John T. Seykora Fei Liu Dany Gaillard Jonathan P. Katz Klaus H. Kaestner Brooke Levin Corinne Mansfield Jennifer E. Douglas Beverly J. Cowart Michael Tordoff Fang Liu Xuming Zhu Linda A. Barlow Adam I. Rubin John A. McGrath Edward E. Morrisey Emily Y. Chu Sarah E. Millar WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation |
| description |
Human WNT10A mutations are associated with dental defects and adult onset ectodermal dysplasia. Xuet al. show that WNT10A-activated ß-catenin plays dual roles in adult epithelial progenitor proliferation and differentiation by complexing with KLF4 in differentiating, but not proliferating, cells. |
| format |
article |
| author |
Mingang Xu Jeremy Horrell Melinda Snitow Jiawei Cui Heather Gochnauer Camille M. Syrett Staci Kallish John T. Seykora Fei Liu Dany Gaillard Jonathan P. Katz Klaus H. Kaestner Brooke Levin Corinne Mansfield Jennifer E. Douglas Beverly J. Cowart Michael Tordoff Fang Liu Xuming Zhu Linda A. Barlow Adam I. Rubin John A. McGrath Edward E. Morrisey Emily Y. Chu Sarah E. Millar |
| author_facet |
Mingang Xu Jeremy Horrell Melinda Snitow Jiawei Cui Heather Gochnauer Camille M. Syrett Staci Kallish John T. Seykora Fei Liu Dany Gaillard Jonathan P. Katz Klaus H. Kaestner Brooke Levin Corinne Mansfield Jennifer E. Douglas Beverly J. Cowart Michael Tordoff Fang Liu Xuming Zhu Linda A. Barlow Adam I. Rubin John A. McGrath Edward E. Morrisey Emily Y. Chu Sarah E. Millar |
| author_sort |
Mingang Xu |
| title |
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation |
| title_short |
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation |
| title_full |
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation |
| title_fullStr |
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation |
| title_full_unstemmed |
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation |
| title_sort |
wnt10a mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and klf4-mediated differentiation |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/155ddb06076c415fa01075d340f6d738 |
| work_keys_str_mv |
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1718386155091656704 |