Chromosomally unstable tumor cells specifically require KIF18A for proliferation

Kinesin motor proteins are critical for maintaining mitotic spindle integrity, which is important for chromosome stability. Here, the authors show that the kinesin motor protein, KIF18A, permits the proliferation of chromosomally unstable cells and knockdown of KIF18A induces centrosome fragmentatio...

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Autores principales:	Carolyn Marquis, Cindy L. Fonseca, Katelyn A. Queen, Lisa Wood, Sarah E. Vandal, Heidi L. H. Malaby, Joseph E. Clayton, Jason Stumpff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/155fe186fe17428f9306cda918e23864
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spelling	oai:doaj.org-article:155fe186fe17428f9306cda918e238642021-12-02T16:23:18ZChromosomally unstable tumor cells specifically require KIF18A for proliferation10.1038/s41467-021-21447-22041-1723https://doaj.org/article/155fe186fe17428f9306cda918e238642021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21447-2https://doaj.org/toc/2041-1723Kinesin motor proteins are critical for maintaining mitotic spindle integrity, which is important for chromosome stability. Here, the authors show that the kinesin motor protein, KIF18A, permits the proliferation of chromosomally unstable cells and knockdown of KIF18A induces centrosome fragmentation.Carolyn MarquisCindy L. FonsecaKatelyn A. QueenLisa WoodSarah E. VandalHeidi L. H. MalabyJoseph E. ClaytonJason StumpffNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carolyn Marquis Cindy L. Fonseca Katelyn A. Queen Lisa Wood Sarah E. Vandal Heidi L. H. Malaby Joseph E. Clayton Jason Stumpff Chromosomally unstable tumor cells specifically require KIF18A for proliferation
description	Kinesin motor proteins are critical for maintaining mitotic spindle integrity, which is important for chromosome stability. Here, the authors show that the kinesin motor protein, KIF18A, permits the proliferation of chromosomally unstable cells and knockdown of KIF18A induces centrosome fragmentation.
format	article
author	Carolyn Marquis Cindy L. Fonseca Katelyn A. Queen Lisa Wood Sarah E. Vandal Heidi L. H. Malaby Joseph E. Clayton Jason Stumpff
author_facet	Carolyn Marquis Cindy L. Fonseca Katelyn A. Queen Lisa Wood Sarah E. Vandal Heidi L. H. Malaby Joseph E. Clayton Jason Stumpff
author_sort	Carolyn Marquis
title	Chromosomally unstable tumor cells specifically require KIF18A for proliferation
title_short	Chromosomally unstable tumor cells specifically require KIF18A for proliferation
title_full	Chromosomally unstable tumor cells specifically require KIF18A for proliferation
title_fullStr	Chromosomally unstable tumor cells specifically require KIF18A for proliferation
title_full_unstemmed	Chromosomally unstable tumor cells specifically require KIF18A for proliferation
title_sort	chromosomally unstable tumor cells specifically require kif18a for proliferation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/155fe186fe17428f9306cda918e23864
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Chromosomally unstable tumor cells specifically require KIF18A for proliferation

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