IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration

Abstract Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression...

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Autores principales:	Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Elisabeth Kremmer, Martin C. Harmsen, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1566807a097949bcbd6e85f9268e49ab
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spelling	oai:doaj.org-article:1566807a097949bcbd6e85f9268e49ab2021-12-02T15:06:00ZIL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration10.1038/s41598-017-17307-z2045-2322https://doaj.org/article/1566807a097949bcbd6e85f9268e49ab2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-17307-zhttps://doaj.org/toc/2045-2322Abstract Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1). Furthermore, FoxQ1 overexpression in RAW cells accelerated TNFα secretion after LPS challenge. Overall, our results indicate that FoxQ1 stimulates monocyte motility, increases pro-inflammatory potential, and directs monocyte migration towards MCP-1 that is crucial for monocyte influx into inflammatory sites. This mechanism could contribute to the pathogenesis of chronic inflammatory disorders such as AD.Ilja OvsiyVladimir RiabovIoannis ManousaridisJulia MichelKondaiah MogantiShuiping YinTengfei LiuCarsten StichtElisabeth KremmerMartin C. HarmsenSergij GoerdtAlexei GratchevJulia KzhyshkowskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilja Ovsiy Vladimir Riabov Ioannis Manousaridis Julia Michel Kondaiah Moganti Shuiping Yin Tengfei Liu Carsten Sticht Elisabeth Kremmer Martin C. Harmsen Sergij Goerdt Alexei Gratchev Julia Kzhyshkowska IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration
description	Abstract Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1). Furthermore, FoxQ1 overexpression in RAW cells accelerated TNFα secretion after LPS challenge. Overall, our results indicate that FoxQ1 stimulates monocyte motility, increases pro-inflammatory potential, and directs monocyte migration towards MCP-1 that is crucial for monocyte influx into inflammatory sites. This mechanism could contribute to the pathogenesis of chronic inflammatory disorders such as AD.
format	article
author	Ilja Ovsiy Vladimir Riabov Ioannis Manousaridis Julia Michel Kondaiah Moganti Shuiping Yin Tengfei Liu Carsten Sticht Elisabeth Kremmer Martin C. Harmsen Sergij Goerdt Alexei Gratchev Julia Kzhyshkowska
author_facet	Ilja Ovsiy Vladimir Riabov Ioannis Manousaridis Julia Michel Kondaiah Moganti Shuiping Yin Tengfei Liu Carsten Sticht Elisabeth Kremmer Martin C. Harmsen Sergij Goerdt Alexei Gratchev Julia Kzhyshkowska
author_sort	Ilja Ovsiy
title	IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration
title_short	IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration
title_full	IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration
title_fullStr	IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration
title_full_unstemmed	IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration
title_sort	il-4 driven transcription factor foxq1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1566807a097949bcbd6e85f9268e49ab
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IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration

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