Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish

Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismu...

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Autores principales:	Miguel Balado, Diego Rey-Varela, Ana M. Albela, Manuel L. Lemos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aquaculture bacterial pathogens vibriosis <i>Vibrio anguillarum</i> bismuth Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/156cc78d29b64b169f7ff2d771cceac9
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spelling	oai:doaj.org-article:156cc78d29b64b169f7ff2d771cceac92021-11-25T18:25:41ZSusceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish10.3390/microorganisms91123992076-2607https://doaj.org/article/156cc78d29b64b169f7ff2d771cceac92021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2399https://doaj.org/toc/2076-2607Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismuth susceptibility in a collection of aquaculture bacterial pathogens. In the presence of bismuth concentrations ranging from 1.3 to 13 µM, most bacteria started showing a drastic decrease in their growth ability, although with high inter- and intraspecific variability. The minimal inhibitory concentrations of bismuth ranged from 13 to more than 780 µM, depending on bacterial species and strain. The results of in vivo assays suggest that low concentrations of bismuth could be especially effective to treat vibriosis caused by <i>Vibrio anguillarum,</i> since bismuth greatly reduced mortality in experimentally infected fish without any observable side effects. A bismuth therapy, alone or combined with other antimicrobials, could contribute to reduce the use of antibiotics in aquaculture.Miguel BaladoDiego Rey-VarelaAna M. AlbelaManuel L. LemosMDPI AGarticleaquaculturebacterial pathogensvibriosis<i>Vibrio anguillarum</i>bismuthBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2399, p 2399 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aquaculture bacterial pathogens vibriosis <i>Vibrio anguillarum</i> bismuth Biology (General) QH301-705.5
spellingShingle	aquaculture bacterial pathogens vibriosis <i>Vibrio anguillarum</i> bismuth Biology (General) QH301-705.5 Miguel Balado Diego Rey-Varela Ana M. Albela Manuel L. Lemos Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish
description	Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismuth susceptibility in a collection of aquaculture bacterial pathogens. In the presence of bismuth concentrations ranging from 1.3 to 13 µM, most bacteria started showing a drastic decrease in their growth ability, although with high inter- and intraspecific variability. The minimal inhibitory concentrations of bismuth ranged from 13 to more than 780 µM, depending on bacterial species and strain. The results of in vivo assays suggest that low concentrations of bismuth could be especially effective to treat vibriosis caused by <i>Vibrio anguillarum,</i> since bismuth greatly reduced mortality in experimentally infected fish without any observable side effects. A bismuth therapy, alone or combined with other antimicrobials, could contribute to reduce the use of antibiotics in aquaculture.
format	article
author	Miguel Balado Diego Rey-Varela Ana M. Albela Manuel L. Lemos
author_facet	Miguel Balado Diego Rey-Varela Ana M. Albela Manuel L. Lemos
author_sort	Miguel Balado
title	Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish
title_short	Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish
title_full	Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish
title_fullStr	Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish
title_full_unstemmed	Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish
title_sort	susceptibility to bismuth(iii) of aquaculture bacterial pathogens: effectiveness of bismuth–deferiprone therapy against <i>vibrio anguillarum</i> infection in fish
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/156cc78d29b64b169f7ff2d771cceac9
work_keys_str_mv	AT miguelbalado susceptibilitytobismuthiiiofaquaculturebacterialpathogenseffectivenessofbismuthdeferipronetherapyagainstivibrioanguillarumiinfectioninfish AT diegoreyvarela susceptibilitytobismuthiiiofaquaculturebacterialpathogenseffectivenessofbismuthdeferipronetherapyagainstivibrioanguillarumiinfectioninfish AT anamalbela susceptibilitytobismuthiiiofaquaculturebacterialpathogenseffectivenessofbismuthdeferipronetherapyagainstivibrioanguillarumiinfectioninfish AT manuelllemos susceptibilitytobismuthiiiofaquaculturebacterialpathogenseffectivenessofbismuthdeferipronetherapyagainstivibrioanguillarumiinfectioninfish
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Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish

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