T–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT

Abstract. A two–stage technology of preparation of T–cell vaccine designated for multiple sclerosis treatment is described. At the first stage myelin–specific lymphocytes undergoe antigen–dependent cultural selection, whereas at the second stage they are grown by means of non–specific stimulation. T...

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Autores principales:	I. P. Ivanova, V. I. Seledzov, N. V. Banul, D. M. Samarin, G. V. Seledzova, I. V. Savkin, V. S. Shyrinsky, N. V. Pronkina, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	т–lymphocytes vaccine multiple sclerosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/156eef87702e4a15b3cdf661fd2847b3
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spelling	oai:doaj.org-article:156eef87702e4a15b3cdf661fd2847b32021-11-18T08:03:41ZT–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT1563-06252313-741X10.15789/1563-0625-2005-1-27-32https://doaj.org/article/156eef87702e4a15b3cdf661fd2847b32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/405https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A two–stage technology of preparation of T–cell vaccine designated for multiple sclerosis treatment is described. At the first stage myelin–specific lymphocytes undergoe antigen–dependent cultural selection, whereas at the second stage they are grown by means of non–specific stimulation. The vaccine prepared in this way was found to induce specific anti–idiotypic immune response, directed against myelin–reactive T–lymphocytes. The results of 1–year follow–up of 18 vaccinated patients with a cerebral–spinal type of multiple sclerosis indicated the absence of side effects of T–cell vaccination, and suggest the possibility of effective application of this treatment within early stages of disease. (Med. Immunol., 2005, vol.7, № 1, pp 27532)I. P. IvanovaV. I. SeledzovN. V. BanulD. M. SamarinG. V. SeledzovaI. V. SavkinV. S. ShyrinskyN. V. PronkinaV. A. KozlovSPb RAACIarticleт–lymphocytesvaccinemultiple sclerosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 1, Pp 27-32 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	т–lymphocytes vaccine multiple sclerosis Immunologic diseases. Allergy RC581-607
spellingShingle	т–lymphocytes vaccine multiple sclerosis Immunologic diseases. Allergy RC581-607 I. P. Ivanova V. I. Seledzov N. V. Banul D. M. Samarin G. V. Seledzova I. V. Savkin V. S. Shyrinsky N. V. Pronkina V. A. Kozlov T–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT
description	Abstract. A two–stage technology of preparation of T–cell vaccine designated for multiple sclerosis treatment is described. At the first stage myelin–specific lymphocytes undergoe antigen–dependent cultural selection, whereas at the second stage they are grown by means of non–specific stimulation. The vaccine prepared in this way was found to induce specific anti–idiotypic immune response, directed against myelin–reactive T–lymphocytes. The results of 1–year follow–up of 18 vaccinated patients with a cerebral–spinal type of multiple sclerosis indicated the absence of side effects of T–cell vaccination, and suggest the possibility of effective application of this treatment within early stages of disease. (Med. Immunol., 2005, vol.7, № 1, pp 27532)
format	article
author	I. P. Ivanova V. I. Seledzov N. V. Banul D. M. Samarin G. V. Seledzova I. V. Savkin V. S. Shyrinsky N. V. Pronkina V. A. Kozlov
author_facet	I. P. Ivanova V. I. Seledzov N. V. Banul D. M. Samarin G. V. Seledzova I. V. Savkin V. S. Shyrinsky N. V. Pronkina V. A. Kozlov
author_sort	I. P. Ivanova
title	T–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT
title_short	T–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT
title_full	T–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT
title_fullStr	T–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT
title_full_unstemmed	T–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT
title_sort	t–cell vaccine preparation for multiple sclerosis treatment
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/156eef87702e4a15b3cdf661fd2847b3
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T–CELL VACCINE PREPARATION FOR MULTIPLE SCLEROSIS TREATMENT

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