The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium

Maryam Vahdat Shariatpanahi,1 Aynaz Velayati,2 Seyed Ali Jamalian,3 Mehdi Babevaynejad,4 Zahra Vahdat Shariatpanahi21Department of Psychiatry, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; 2National Nutrition and Food Technology Research Institute, Faculty of N...

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Autores principales:	Vahdat Shariatpanahi M, Velayati A, Jamalian SA, Babevaynejad M, Vahdat Shariatpanahi Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Vitamin B12 CAM-ICU Cardiopulmonary bypass Intensive care unit Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/157148c533d6445e8531e0beae9d7348
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spelling	oai:doaj.org-article:157148c533d6445e8531e0beae9d73482021-12-02T08:14:21ZThe relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium1178-2021https://doaj.org/article/157148c533d6445e8531e0beae9d73482019-05-01T00:00:00Zhttps://www.dovepress.com/the-relationship-between-serum-cobalamin-folic-acid-and-homocysteine-a-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Maryam Vahdat Shariatpanahi,1 Aynaz Velayati,2 Seyed Ali Jamalian,3 Mehdi Babevaynejad,4 Zahra Vahdat Shariatpanahi21Department of Psychiatry, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; 2National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Department of Cardiology, Shahid Lavasani Hospital, Islamic Azad University, Tehran, Iran; 4Department of Cardiac Surgery, Shahid Lavasani Hospital, Islamic Azad University, Tehran, IranPurpose: It has been reported that cobalamin and folate deficiency is related to delirium in persons with dementia. We evaluated the association of admission serum levels of cobalamin, folic acid, and homocysteine with the occurrence of acute delirium after coronary artery bypass surgery.Methods: In this prospective cohort study, serum levels of cobalamin, folic acid, and homocysteine were measured for 296 patients upon admission. Delirium was defined by the confusion assessment method for the intensive care unit.Results: Postoperative delirium was detected in 23% (n=68) of patients. Cobalamin deficiency, folate deficiency, and hyperhomocysteinemia were observed in 29% (n=86), 6% (n=18), and 68% (n=200) of patients, respectively. The mean ± SD serum levels of folic acid were 10.77±5.39 ng/mL and 12.86±6.51 ng/mL in delirium and non-delirium patients, respectively (P=0.008). The median (interquartile range [IQR]) serum levels of cobalamin were 280 (216–351) and 247 (195.5–336) in delirium and non-delirium patients, respectively (P=0.09). The median (IQR) serum levels of homocysteine were 18.5 (14.5–22.1) μmol/L and 17.33 (14.2–23.2) μmol/L in delirium and non-delirium patients, respectively (P=0.94). Multivariate regression analysis adjusted by other risk factors indicated that serum homocysteine, folate, and cobalamin levels had no association with the occurrence of delirium.Conclusion: There was no relationship between the preoperative levels of cobalamin, folate, and homocysteine, and acute occurrence of delirium observed after cardiac surgery.Keywords: vitamin B12, CAM-ICU, cardiopulmonary bypass, intensive care unitVahdat Shariatpanahi MVelayati AJamalian SABabevaynejad MVahdat Shariatpanahi ZDove Medical PressarticleVitamin B12CAM-ICUCardiopulmonary bypassIntensive care unitNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1413-1419 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitamin B12 CAM-ICU Cardiopulmonary bypass Intensive care unit Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Vitamin B12 CAM-ICU Cardiopulmonary bypass Intensive care unit Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Vahdat Shariatpanahi M Velayati A Jamalian SA Babevaynejad M Vahdat Shariatpanahi Z The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium
description	Maryam Vahdat Shariatpanahi,1 Aynaz Velayati,2 Seyed Ali Jamalian,3 Mehdi Babevaynejad,4 Zahra Vahdat Shariatpanahi21Department of Psychiatry, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; 2National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Department of Cardiology, Shahid Lavasani Hospital, Islamic Azad University, Tehran, Iran; 4Department of Cardiac Surgery, Shahid Lavasani Hospital, Islamic Azad University, Tehran, IranPurpose: It has been reported that cobalamin and folate deficiency is related to delirium in persons with dementia. We evaluated the association of admission serum levels of cobalamin, folic acid, and homocysteine with the occurrence of acute delirium after coronary artery bypass surgery.Methods: In this prospective cohort study, serum levels of cobalamin, folic acid, and homocysteine were measured for 296 patients upon admission. Delirium was defined by the confusion assessment method for the intensive care unit.Results: Postoperative delirium was detected in 23% (n=68) of patients. Cobalamin deficiency, folate deficiency, and hyperhomocysteinemia were observed in 29% (n=86), 6% (n=18), and 68% (n=200) of patients, respectively. The mean ± SD serum levels of folic acid were 10.77±5.39 ng/mL and 12.86±6.51 ng/mL in delirium and non-delirium patients, respectively (P=0.008). The median (interquartile range [IQR]) serum levels of cobalamin were 280 (216–351) and 247 (195.5–336) in delirium and non-delirium patients, respectively (P=0.09). The median (IQR) serum levels of homocysteine were 18.5 (14.5–22.1) μmol/L and 17.33 (14.2–23.2) μmol/L in delirium and non-delirium patients, respectively (P=0.94). Multivariate regression analysis adjusted by other risk factors indicated that serum homocysteine, folate, and cobalamin levels had no association with the occurrence of delirium.Conclusion: There was no relationship between the preoperative levels of cobalamin, folate, and homocysteine, and acute occurrence of delirium observed after cardiac surgery.Keywords: vitamin B12, CAM-ICU, cardiopulmonary bypass, intensive care unit
format	article
author	Vahdat Shariatpanahi M Velayati A Jamalian SA Babevaynejad M Vahdat Shariatpanahi Z
author_facet	Vahdat Shariatpanahi M Velayati A Jamalian SA Babevaynejad M Vahdat Shariatpanahi Z
author_sort	Vahdat Shariatpanahi M
title	The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium
title_short	The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium
title_full	The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium
title_fullStr	The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium
title_full_unstemmed	The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium
title_sort	relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/157148c533d6445e8531e0beae9d7348
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The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium

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