Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice
Seyran Hosseini,1 Amir Nili-Ahmadabadi,2,3 Seyed Mostafa Nachvak,4,5 Dara Dastan,2,6 Shima Moradi,4,5 Hadi Abdollahzad,4,5 Roghayeh Mostafai4,5 1Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Medicinal Pla...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2020
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| Acceso en línea: | https://doaj.org/article/1575cac0b3c34eac827209adf86ee852 |
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| Sumario: | Seyran Hosseini,1 Amir Nili-Ahmadabadi,2,3 Seyed Mostafa Nachvak,4,5 Dara Dastan,2,6 Shima Moradi,4,5 Hadi Abdollahzad,4,5 Roghayeh Mostafai4,5 1Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 3Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; 4Nutritional Sciences Department, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 6Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranCorrespondence: Seyed Mostafa NachvakNutritional Sciences Department, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, IranTel +98 83 37102003Fax +98 83 38263048Email smnachvak@hotmail.comDara DastanMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranTel +98 8138381590Fax +98 8138380031Email d.dastan@umsha.ac.irIntroduction: Pistacia atlantica subsp. kurdica is an important food source and a well-known medicinal plant in the Zagros Mountains of Iran. The present study aimed to investigate the effect of P. atlantica extract and essential oil in streptozotocin-induced diabetic mice.Materials and Methods: Different doses of hydroalcoholic extract and essential oil of P. atlantica subsp. kurdica (50, 100, and 200 mg/kg) were given to streptozotocin-induced diabetic mice in separate groups for three weeks. At the end of treatment, blood samples were collected; then, oxidative stress markers, TNF-α, and lipid profile were determined in its serum samples.Results: Our findings showed that the administration of P. atlantica extract for three consecutive weeks significantly improved the lipid profile, oxidative stress, and inflammation process by reducing lipid peroxidation and increasing total antioxidant capacity.Conclusion: This study showed that P. atlantica subsp. kurdica has antioxidant and blood lipid-lowering effects that can be used as a supplement to improve diabetes complications.Keywords: Pistacia atlantica subsp. kurdica, phytochemical, diabetes, lipid profile, oxidative stress |
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