Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice

Seyran Hosseini,1 Amir Nili-Ahmadabadi,2,3 Seyed Mostafa Nachvak,4,5 Dara Dastan,2,6 Shima Moradi,4,5 Hadi Abdollahzad,4,5 Roghayeh Mostafai4,5 1Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Medicinal Pla...

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Autores principales:	Hosseini S, Nili-Ahmadabadi A, Nachvak SM, Dastan D, Moradi S, Abdollahzad H, Mostafai R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	pistacia atlantica subsp. kurdica phytochemical diabetes lipid profile oxidative stress. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1575cac0b3c34eac827209adf86ee852
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spelling	oai:doaj.org-article:1575cac0b3c34eac827209adf86ee8522021-12-02T09:33:16ZAntihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice1178-7007https://doaj.org/article/1575cac0b3c34eac827209adf86ee8522020-04-01T00:00:00Zhttps://www.dovepress.com/antihyperlipidemic-and-antioxidative-properties-of-pistacia-atlantica--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Seyran Hosseini,1 Amir Nili-Ahmadabadi,2,3 Seyed Mostafa Nachvak,4,5 Dara Dastan,2,6 Shima Moradi,4,5 Hadi Abdollahzad,4,5 Roghayeh Mostafai4,5 1Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 3Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; 4Nutritional Sciences Department, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 6Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranCorrespondence: Seyed Mostafa NachvakNutritional Sciences Department, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, IranTel +98 83 37102003Fax +98 83 38263048Email smnachvak@hotmail.comDara DastanMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranTel +98 8138381590Fax +98 8138380031Email d.dastan@umsha.ac.irIntroduction: Pistacia atlantica subsp. kurdica is an important food source and a well-known medicinal plant in the Zagros Mountains of Iran. The present study aimed to investigate the effect of P. atlantica extract and essential oil in streptozotocin-induced diabetic mice.Materials and Methods: Different doses of hydroalcoholic extract and essential oil of P. atlantica subsp. kurdica (50, 100, and 200 mg/kg) were given to streptozotocin-induced diabetic mice in separate groups for three weeks. At the end of treatment, blood samples were collected; then, oxidative stress markers, TNF-α, and lipid profile were determined in its serum samples.Results: Our findings showed that the administration of P. atlantica extract for three consecutive weeks significantly improved the lipid profile, oxidative stress, and inflammation process by reducing lipid peroxidation and increasing total antioxidant capacity.Conclusion: This study showed that P. atlantica subsp. kurdica has antioxidant and blood lipid-lowering effects that can be used as a supplement to improve diabetes complications.Keywords: Pistacia atlantica subsp. kurdica, phytochemical, diabetes, lipid profile, oxidative stressHosseini SNili-Ahmadabadi ANachvak SMDastan DMoradi SAbdollahzad HMostafai RDove Medical Pressarticlepistacia atlantica subsp. kurdicaphytochemicaldiabeteslipid profileoxidative stress.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1231-1236 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pistacia atlantica subsp. kurdica phytochemical diabetes lipid profile oxidative stress. Specialties of internal medicine RC581-951
spellingShingle	pistacia atlantica subsp. kurdica phytochemical diabetes lipid profile oxidative stress. Specialties of internal medicine RC581-951 Hosseini S Nili-Ahmadabadi A Nachvak SM Dastan D Moradi S Abdollahzad H Mostafai R Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice
description	Seyran Hosseini,1 Amir Nili-Ahmadabadi,2,3 Seyed Mostafa Nachvak,4,5 Dara Dastan,2,6 Shima Moradi,4,5 Hadi Abdollahzad,4,5 Roghayeh Mostafai4,5 1Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 3Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; 4Nutritional Sciences Department, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 6Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranCorrespondence: Seyed Mostafa NachvakNutritional Sciences Department, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, IranTel +98 83 37102003Fax +98 83 38263048Email smnachvak@hotmail.comDara DastanMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranTel +98 8138381590Fax +98 8138380031Email d.dastan@umsha.ac.irIntroduction: Pistacia atlantica subsp. kurdica is an important food source and a well-known medicinal plant in the Zagros Mountains of Iran. The present study aimed to investigate the effect of P. atlantica extract and essential oil in streptozotocin-induced diabetic mice.Materials and Methods: Different doses of hydroalcoholic extract and essential oil of P. atlantica subsp. kurdica (50, 100, and 200 mg/kg) were given to streptozotocin-induced diabetic mice in separate groups for three weeks. At the end of treatment, blood samples were collected; then, oxidative stress markers, TNF-α, and lipid profile were determined in its serum samples.Results: Our findings showed that the administration of P. atlantica extract for three consecutive weeks significantly improved the lipid profile, oxidative stress, and inflammation process by reducing lipid peroxidation and increasing total antioxidant capacity.Conclusion: This study showed that P. atlantica subsp. kurdica has antioxidant and blood lipid-lowering effects that can be used as a supplement to improve diabetes complications.Keywords: Pistacia atlantica subsp. kurdica, phytochemical, diabetes, lipid profile, oxidative stress
format	article
author	Hosseini S Nili-Ahmadabadi A Nachvak SM Dastan D Moradi S Abdollahzad H Mostafai R
author_facet	Hosseini S Nili-Ahmadabadi A Nachvak SM Dastan D Moradi S Abdollahzad H Mostafai R
author_sort	Hosseini S
title	Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice
title_short	Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice
title_full	Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice
title_fullStr	Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice
title_full_unstemmed	Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice
title_sort	antihyperlipidemic and antioxidative properties of pistacia atlantica subsp. kurdica in streptozotocin-induced diabetic mice
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1575cac0b3c34eac827209adf86ee852
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Antihyperlipidemic and Antioxidative Properties of Pistacia atlantica subsp. kurdica in Streptozotocin-Induced Diabetic Mice

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