The heat shock response and humoral immune response are mutually antagonistic in honey bees

Abstract The honey bee is of paramount importance to humans in both agricultural and ecological settings. Honey bee colonies have suffered from increased attrition in recent years, stemming from complex interacting stresses. Defining common cellular stress responses elicited by these stressors repre...

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Autores principales:	Mia McKinstry, Charlie Chung, Henry Truong, Brittany A. Johnston, Jonathan W. Snow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/157bfc3e7da944b19dad33a129cd4a4e
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spelling	oai:doaj.org-article:157bfc3e7da944b19dad33a129cd4a4e2021-12-02T12:31:45ZThe heat shock response and humoral immune response are mutually antagonistic in honey bees10.1038/s41598-017-09159-42045-2322https://doaj.org/article/157bfc3e7da944b19dad33a129cd4a4e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09159-4https://doaj.org/toc/2045-2322Abstract The honey bee is of paramount importance to humans in both agricultural and ecological settings. Honey bee colonies have suffered from increased attrition in recent years, stemming from complex interacting stresses. Defining common cellular stress responses elicited by these stressors represents a key step in understanding potential synergies. The proteostasis network is a highly conserved network of cellular stress responses involved in maintaining the homeostasis of protein production and function. Here, we have characterized the Heat Shock Response (HSR), one branch of this network, and found that its core components are conserved. In addition, exposing bees to elevated temperatures normally encountered by honey bees during typical activities results in robust HSR induction with increased expression of specific heat shock proteins that was variable across tissues. Surprisingly, we found that heat shock represses multiple immune genes in the abdomen and additionally showed that wounding the cuticle of the abdomen results in decreased expression of multiple HSR genes in proximal and distal tissues. This mutually antagonistic relationship between the HSR and immune activation is unique among invertebrates studied to date and may promote understanding of potential synergistic effects of disparate stresses in this critical pollinator and social insects more broadly.Mia McKinstryCharlie ChungHenry TruongBrittany A. JohnstonJonathan W. SnowNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mia McKinstry Charlie Chung Henry Truong Brittany A. Johnston Jonathan W. Snow The heat shock response and humoral immune response are mutually antagonistic in honey bees
description	Abstract The honey bee is of paramount importance to humans in both agricultural and ecological settings. Honey bee colonies have suffered from increased attrition in recent years, stemming from complex interacting stresses. Defining common cellular stress responses elicited by these stressors represents a key step in understanding potential synergies. The proteostasis network is a highly conserved network of cellular stress responses involved in maintaining the homeostasis of protein production and function. Here, we have characterized the Heat Shock Response (HSR), one branch of this network, and found that its core components are conserved. In addition, exposing bees to elevated temperatures normally encountered by honey bees during typical activities results in robust HSR induction with increased expression of specific heat shock proteins that was variable across tissues. Surprisingly, we found that heat shock represses multiple immune genes in the abdomen and additionally showed that wounding the cuticle of the abdomen results in decreased expression of multiple HSR genes in proximal and distal tissues. This mutually antagonistic relationship between the HSR and immune activation is unique among invertebrates studied to date and may promote understanding of potential synergistic effects of disparate stresses in this critical pollinator and social insects more broadly.
format	article
author	Mia McKinstry Charlie Chung Henry Truong Brittany A. Johnston Jonathan W. Snow
author_facet	Mia McKinstry Charlie Chung Henry Truong Brittany A. Johnston Jonathan W. Snow
author_sort	Mia McKinstry
title	The heat shock response and humoral immune response are mutually antagonistic in honey bees
title_short	The heat shock response and humoral immune response are mutually antagonistic in honey bees
title_full	The heat shock response and humoral immune response are mutually antagonistic in honey bees
title_fullStr	The heat shock response and humoral immune response are mutually antagonistic in honey bees
title_full_unstemmed	The heat shock response and humoral immune response are mutually antagonistic in honey bees
title_sort	heat shock response and humoral immune response are mutually antagonistic in honey bees
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/157bfc3e7da944b19dad33a129cd4a4e
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The heat shock response and humoral immune response are mutually antagonistic in honey bees

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