Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.

Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm t...

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Autores principales:	Linda Olsson, Kajsa Paulsson, Judith V M G Bovée, Karolin H Nord
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/157d89259dfe4750b437d723483d21f6
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spelling	oai:doaj.org-article:157d89259dfe4750b437d723483d21f62021-11-04T06:08:12ZClonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.1932-620310.1371/journal.pone.0024977https://doaj.org/article/157d89259dfe4750b437d723483d21f62011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949816/?tool=EBIhttps://doaj.org/toc/1932-6203Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. Sixteen chondrosarcomas were investigated by single nucleotide polymorphism (SNP) array and the majority displayed SNP patterns indicative of a hyperhaploid-hypodiploid origin, with or without subsequent polyploidization. Except for chromosomes 5, 7, 19, 20 and 21, autosomal loss of heterozygosity was commonly found, resulting from chromosome loss and subsequent duplication of monosomic chromosomes giving rise to uniparental disomy. Additional gains, losses and rearrangements of genetic material, and even repeated rounds of polyploidization, may affect chondrosarcoma cells resulting in highly complex karyotypes. Loss of chromosomes and subsequent polyploidization was not restricted to a particular chondrosarcoma subtype and, although commonly found in chondrosarcoma, binucleated cells did not seem to be involved in these events.Linda OlssonKajsa PaulssonJudith V M G BovéeKarolin H NordPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24977 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linda Olsson Kajsa Paulsson Judith V M G Bovée Karolin H Nord Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.
description	Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. Sixteen chondrosarcomas were investigated by single nucleotide polymorphism (SNP) array and the majority displayed SNP patterns indicative of a hyperhaploid-hypodiploid origin, with or without subsequent polyploidization. Except for chromosomes 5, 7, 19, 20 and 21, autosomal loss of heterozygosity was commonly found, resulting from chromosome loss and subsequent duplication of monosomic chromosomes giving rise to uniparental disomy. Additional gains, losses and rearrangements of genetic material, and even repeated rounds of polyploidization, may affect chondrosarcoma cells resulting in highly complex karyotypes. Loss of chromosomes and subsequent polyploidization was not restricted to a particular chondrosarcoma subtype and, although commonly found in chondrosarcoma, binucleated cells did not seem to be involved in these events.
format	article
author	Linda Olsson Kajsa Paulsson Judith V M G Bovée Karolin H Nord
author_facet	Linda Olsson Kajsa Paulsson Judith V M G Bovée Karolin H Nord
author_sort	Linda Olsson
title	Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.
title_short	Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.
title_full	Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.
title_fullStr	Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.
title_full_unstemmed	Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.
title_sort	clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/157d89259dfe4750b437d723483d21f6
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Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma.

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