Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation

Background: Previous studies have shown that neurons of the cerebral cortex can be injured by implantation of, and stimulation with, implanted microelectrodes. Objectives: Objective 1 was to determine parameters of microstimulation delivered through multisite intracortical microelectrode arrays that...

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Autores principales:	Douglas McCreery, Martin Han, Victor Pikov, Carol Miller
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Intracortical microelectrodes Neural loss during electrical stimulation Stimulus charge density Stimulus charge per phase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/157e221445674f5b976faa932ac769ed
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spelling	oai:doaj.org-article:157e221445674f5b976faa932ac769ed2021-11-20T05:02:52ZConfiguring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation1935-861X10.1016/j.brs.2021.10.385https://doaj.org/article/157e221445674f5b976faa932ac769ed2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1935861X21006318https://doaj.org/toc/1935-861XBackground: Previous studies have shown that neurons of the cerebral cortex can be injured by implantation of, and stimulation with, implanted microelectrodes. Objectives: Objective 1 was to determine parameters of microstimulation delivered through multisite intracortical microelectrode arrays that will activate neurons of the feline cerebral cortex without causing loss of neurons. Objective: 2 was to determine if the stimulus parameters that induced loss of cortical neurons differed for all cortical neurons vs. the subset of inhibitory neurons expressing parvalbumin. Methods: The intracortical microstimulation was applied for 7 h/day for 20 days (140 h). Microelectrode site areas were 2000 and 4000 μm2, Q was 2–8 nanocoulombs (nC) at 50 Hz, and QD was 50–400 μcoulombs/cm2. Results: Neuron loss due to stimulation was minimal at Q = 2 Ncp, but at 8 Ncp, 20%–50% of neurons within 250 μm of the stimulated microelectrodes were lost, compared to unstimulated microelectrodes. Loss was greatest in tissue facing electrode sites. Stimulation-induced loss was similar for neurons labeled for NeuN and for inhibitory neurons expressing parvalbumin. Correlation between neuron loss and QD was not significant.Electrodes in the medullary pyramidal tract recorded neuronal activity evoked by stimulation in the cerebral cortex. The pyramidal neurons were activated by intracortical stimulation of 2 nC/phase. 140 h of microstimulation at 2 nC/phase and 50 Hz induced minimal neuron loss.Douglas McCreeryMartin HanVictor PikovCarol MillerElsevierarticleIntracortical microelectrodesNeural loss during electrical stimulationStimulus charge densityStimulus charge per phaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Stimulation, Vol 14, Iss 6, Pp 1553-1562 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intracortical microelectrodes Neural loss during electrical stimulation Stimulus charge density Stimulus charge per phase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Intracortical microelectrodes Neural loss during electrical stimulation Stimulus charge density Stimulus charge per phase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Douglas McCreery Martin Han Victor Pikov Carol Miller Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation
description	Background: Previous studies have shown that neurons of the cerebral cortex can be injured by implantation of, and stimulation with, implanted microelectrodes. Objectives: Objective 1 was to determine parameters of microstimulation delivered through multisite intracortical microelectrode arrays that will activate neurons of the feline cerebral cortex without causing loss of neurons. Objective: 2 was to determine if the stimulus parameters that induced loss of cortical neurons differed for all cortical neurons vs. the subset of inhibitory neurons expressing parvalbumin. Methods: The intracortical microstimulation was applied for 7 h/day for 20 days (140 h). Microelectrode site areas were 2000 and 4000 μm2, Q was 2–8 nanocoulombs (nC) at 50 Hz, and QD was 50–400 μcoulombs/cm2. Results: Neuron loss due to stimulation was minimal at Q = 2 Ncp, but at 8 Ncp, 20%–50% of neurons within 250 μm of the stimulated microelectrodes were lost, compared to unstimulated microelectrodes. Loss was greatest in tissue facing electrode sites. Stimulation-induced loss was similar for neurons labeled for NeuN and for inhibitory neurons expressing parvalbumin. Correlation between neuron loss and QD was not significant.Electrodes in the medullary pyramidal tract recorded neuronal activity evoked by stimulation in the cerebral cortex. The pyramidal neurons were activated by intracortical stimulation of 2 nC/phase. 140 h of microstimulation at 2 nC/phase and 50 Hz induced minimal neuron loss.
format	article
author	Douglas McCreery Martin Han Victor Pikov Carol Miller
author_facet	Douglas McCreery Martin Han Victor Pikov Carol Miller
author_sort	Douglas McCreery
title	Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation
title_short	Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation
title_full	Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation
title_fullStr	Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation
title_full_unstemmed	Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation
title_sort	configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/157e221445674f5b976faa932ac769ed
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Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation

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