Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis

Abstract We intended to investigate whether muscle and adipose masses were associated with prognosis among patients with stage III non-small-cell lung cancer (NSCLC) who were undergoing chemoradiotherapy (CCRT). We retrospectively explored data of patients with stage III NSCLC who underwent definiti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kuniaki Katsui, Takeshi Ogata, Soichi Sugiyama, Kotaro Yoshio, Masahiro Kuroda, Takao Hiraki, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka, Susumu Kanazawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15828e7ac9f34f73885540f92238ed2e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:15828e7ac9f34f73885540f92238ed2e
record_format	dspace
spelling	oai:doaj.org-article:15828e7ac9f34f73885540f92238ed2e2021-12-02T15:57:03ZSarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis10.1038/s41598-021-91449-z2045-2322https://doaj.org/article/15828e7ac9f34f73885540f92238ed2e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91449-zhttps://doaj.org/toc/2045-2322Abstract We intended to investigate whether muscle and adipose masses were associated with prognosis among patients with stage III non-small-cell lung cancer (NSCLC) who were undergoing chemoradiotherapy (CCRT). We retrospectively explored data of patients with stage III NSCLC who underwent definitive CCRT (≥ 60 Gy) between January 2004 and March 2018 at our hospital. We examined the relationship of overall survival (OS) with body mass index (BMI), skeletal muscle index (SMI), psoas muscle index (PMI), visceral adipose tissue index (VAI), subcutaneous adipose tissue index (SAI), and visceral-to-subcutaneous adipose tissue area ratio (VSR) using log-rank tests for the univariate analysis and Cox proportional hazard models for the multivariate analysis. Overall, 16, 32, and 12 patients had stage IIIA, IIIB, and IIIC NSCLC, respectively. The total radiotherapy dose ranged from 60 Gy/30 fractions to 66 Gy/33 fractions. In the univariate analysis, the performance status (PS), BMI, and SMI were associated with OS, whereas the PMI, VAI, SAI, and VSR were not. In the multivariate analysis, the PS and SMI were associated with OS. The hazard ratios and 95% confidence intervals were 2.91 and 1.28–6.64 for PS, and 2.36 and 1.15–4.85 for SMI, respectively. The 1, 3, and 5-year OS rates were 92.1%, 59.6%, and 51.0% in patients with high SMI, and 63.6%, 53.8%, and 17.9% in patients with low SMI, respectively. The SMI correlated with prognosis in our study population, whereas adipose mass did not. Therefore, sarcopenia should be considered while predicting the OS in such patients.Kuniaki KatsuiTakeshi OgataSoichi SugiyamaKotaro YoshioMasahiro KurodaTakao HirakiKatsuyuki KiuraYoshinobu MaedaShinichi ToyookaSusumu KanazawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuniaki Katsui Takeshi Ogata Soichi Sugiyama Kotaro Yoshio Masahiro Kuroda Takao Hiraki Katsuyuki Kiura Yoshinobu Maeda Shinichi Toyooka Susumu Kanazawa Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis
description	Abstract We intended to investigate whether muscle and adipose masses were associated with prognosis among patients with stage III non-small-cell lung cancer (NSCLC) who were undergoing chemoradiotherapy (CCRT). We retrospectively explored data of patients with stage III NSCLC who underwent definitive CCRT (≥ 60 Gy) between January 2004 and March 2018 at our hospital. We examined the relationship of overall survival (OS) with body mass index (BMI), skeletal muscle index (SMI), psoas muscle index (PMI), visceral adipose tissue index (VAI), subcutaneous adipose tissue index (SAI), and visceral-to-subcutaneous adipose tissue area ratio (VSR) using log-rank tests for the univariate analysis and Cox proportional hazard models for the multivariate analysis. Overall, 16, 32, and 12 patients had stage IIIA, IIIB, and IIIC NSCLC, respectively. The total radiotherapy dose ranged from 60 Gy/30 fractions to 66 Gy/33 fractions. In the univariate analysis, the performance status (PS), BMI, and SMI were associated with OS, whereas the PMI, VAI, SAI, and VSR were not. In the multivariate analysis, the PS and SMI were associated with OS. The hazard ratios and 95% confidence intervals were 2.91 and 1.28–6.64 for PS, and 2.36 and 1.15–4.85 for SMI, respectively. The 1, 3, and 5-year OS rates were 92.1%, 59.6%, and 51.0% in patients with high SMI, and 63.6%, 53.8%, and 17.9% in patients with low SMI, respectively. The SMI correlated with prognosis in our study population, whereas adipose mass did not. Therefore, sarcopenia should be considered while predicting the OS in such patients.
format	article
author	Kuniaki Katsui Takeshi Ogata Soichi Sugiyama Kotaro Yoshio Masahiro Kuroda Takao Hiraki Katsuyuki Kiura Yoshinobu Maeda Shinichi Toyooka Susumu Kanazawa
author_facet	Kuniaki Katsui Takeshi Ogata Soichi Sugiyama Kotaro Yoshio Masahiro Kuroda Takao Hiraki Katsuyuki Kiura Yoshinobu Maeda Shinichi Toyooka Susumu Kanazawa
author_sort	Kuniaki Katsui
title	Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis
title_short	Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis
title_full	Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis
title_fullStr	Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis
title_full_unstemmed	Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis
title_sort	sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage iii non-small-cell lung cancer: a retrospective analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15828e7ac9f34f73885540f92238ed2e
work_keys_str_mv	AT kuniakikatsui sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT takeshiogata sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT soichisugiyama sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT kotaroyoshio sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT masahirokuroda sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT takaohiraki sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT katsuyukikiura sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT yoshinobumaeda sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT shinichitoyooka sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis AT susumukanazawa sarcopeniaisassociatedwithpoorprognosisafterchemoradiotherapyinpatientswithstageiiinonsmallcelllungcanceraretrospectiveanalysis
_version_	1718385374240178176

Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis

Ejemplares similares