Structural basis of the association of HIV-1 matrix protein with DNA.

Structural basis of the association of HIV-1 matrix protein with DNA.

HIV-1 matrix (MA) is a multifunctional protein that is synthesized as a polyprotein that is cleaved by protease during viral maturation. MA contains a cluster of basic residues whose role is controversial. Proposed functions include membrane anchoring, facilitating viral assembly, and directing nucl...

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Autores principales: Mengli Cai, Ying Huang, Robert Craigie, G Marius Clore
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/158391aa08ec49119ed349722d2af401
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spelling oai:doaj.org-article:158391aa08ec49119ed349722d2af4012021-11-18T07:01:12ZStructural basis of the association of HIV-1 matrix protein with DNA.1932-620310.1371/journal.pone.0015675https://doaj.org/article/158391aa08ec49119ed349722d2af4012010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21203471/?tool=EBIhttps://doaj.org/toc/1932-6203HIV-1 matrix (MA) is a multifunctional protein that is synthesized as a polyprotein that is cleaved by protease during viral maturation. MA contains a cluster of basic residues whose role is controversial. Proposed functions include membrane anchoring, facilitating viral assembly, and directing nuclear import of the viral DNA. Since MA has been reported to be a component of the preintegration complex (PIC), we have used NMR to probe its interaction with other PIC components. We show that MA interacts with DNA and this is likely sufficient to account for its association with the PIC.Mengli CaiYing HuangRobert CraigieG Marius ClorePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e15675 (2010)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Mengli Cai
Ying Huang
Robert Craigie
G Marius Clore
Structural basis of the association of HIV-1 matrix protein with DNA.
description HIV-1 matrix (MA) is a multifunctional protein that is synthesized as a polyprotein that is cleaved by protease during viral maturation. MA contains a cluster of basic residues whose role is controversial. Proposed functions include membrane anchoring, facilitating viral assembly, and directing nuclear import of the viral DNA. Since MA has been reported to be a component of the preintegration complex (PIC), we have used NMR to probe its interaction with other PIC components. We show that MA interacts with DNA and this is likely sufficient to account for its association with the PIC.
format article
author Mengli Cai
Ying Huang
Robert Craigie
G Marius Clore
author_facet Mengli Cai
Ying Huang
Robert Craigie
G Marius Clore
author_sort Mengli Cai
title Structural basis of the association of HIV-1 matrix protein with DNA.
title_short Structural basis of the association of HIV-1 matrix protein with DNA.
title_full Structural basis of the association of HIV-1 matrix protein with DNA.
title_fullStr Structural basis of the association of HIV-1 matrix protein with DNA.
title_full_unstemmed Structural basis of the association of HIV-1 matrix protein with DNA.
title_sort structural basis of the association of hiv-1 matrix protein with dna.
publisher Public Library of Science (PLoS)
publishDate 2010
url https://doaj.org/article/158391aa08ec49119ed349722d2af401
work_keys_str_mv AT menglicai structuralbasisoftheassociationofhiv1matrixproteinwithdna
AT yinghuang structuralbasisoftheassociationofhiv1matrixproteinwithdna
AT robertcraigie structuralbasisoftheassociationofhiv1matrixproteinwithdna
AT gmariusclore structuralbasisoftheassociationofhiv1matrixproteinwithdna
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